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Published in: Seminars in Immunopathology 3/2020

01-06-2020 | Nutrition | Review

Immunometabolism: new insights and lessons from antigen-directed cellular immune responses

Authors: Renata Ramalho, Martin Rao, Chao Zhang, Chiara Agrati, Giuseppe Ippolito, Fu-Sheng Wang, Alimuddin Zumla, Markus Maeurer

Published in: Seminars in Immunopathology | Issue 3/2020

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Abstract

Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular persistence in chronic infections. We also highlight the role of nutrients in altering the tissue microenvironment with lessons from the tumor microenvironment that shapes the quality and quantity of cellular immune responses. Multiple layers of biological networks, including the nature of nutritional supplements, the genetic background, previous exposures, and gut microbiota status have impact on cellular performance and immune competence against molecularly defined targets. We discuss how immune metabolism determines the differentiation pathway of antigen-specific immune cells and how these insights can be explored to devise better strategies to strengthen anti-pathogen-directed immune responses, while curbing unwanted, non-productive inflammation.
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Metadata
Title
Immunometabolism: new insights and lessons from antigen-directed cellular immune responses
Authors
Renata Ramalho
Martin Rao
Chao Zhang
Chiara Agrati
Giuseppe Ippolito
Fu-Sheng Wang
Alimuddin Zumla
Markus Maeurer
Publication date
01-06-2020
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 3/2020
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-020-00798-w

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