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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2015

Open Access 01-03-2015 | Review

Interference of Aspergillus fumigatus with the immune response

Authors: Thorsten Heinekamp, Hella Schmidt, Katrin Lapp, Vera Pähtz, Iordana Shopova, Nora Köster-Eiserfunke, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage

Published in: Seminars in Immunopathology | Issue 2/2015

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Abstract

Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host’s immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impaired immunity. In contrast to the majority of other Aspergillus species, which are in most cases nonpathogenic, A. fumigatus features an armory of virulence determinants to establish an infection. For example, A. fumigatus is able to evade the human complement system by binding or degrading complement regulators. Furthermore, the fungus interferes with lung epithelial cells, alveolar macrophages, and neutrophil granulocytes to prevent killing by these immune cells. This chapter summarizes the different strategies of A. fumigatus to manipulate the immune response. We also discuss the potential impact of recent advances in immunoproteomics to improve diagnosis and therapy of an A. fumigatus infection.
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Metadata
Title
Interference of Aspergillus fumigatus with the immune response
Authors
Thorsten Heinekamp
Hella Schmidt
Katrin Lapp
Vera Pähtz
Iordana Shopova
Nora Köster-Eiserfunke
Thomas Krüger
Olaf Kniemeyer
Axel A. Brakhage
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 2/2015
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-014-0465-1

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