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01-04-2010 | Original Article

Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases

Authors: Hidekazu Kuramochi, Kazuhiko Hayashi, Go Nakajima, Hirotaka Kamikozuru, Masakazu Yamamoto, Kathleen D. Danenberg, Peter V. Danenberg

Published in: Cancer Chemotherapy and Pharmacology | Issue 5/2010

Abstract

Purpose

High expression levels of EGFR mRNA are reported to be associated with a higher response probability in epidermal growth factor receptor (EGFR) targeted drugs. Our aim was to determine how EGFR gene expression levels in primary colorectal cancer (CRC) were related to those in liver metastases.

Methods

31 pairs of primary CRC and corresponding liver metastases were analyzed. Gene expression level was measured using real-time RT-PCR.

Results

No significant difference was observed between median mRNA expression levels of EGFR in primary cancer and those in corresponding liver metastases (P = 0.99). When matched tissue sets were compared on an individual basis, there was a significant correlation for EGFR mRNA expression between primary cancer and corresponding liver metastases (r _s = 0.78, P < 0.0001).

Conclusions

A good prediction of EGFR mRNA levels in liver metastases can be obtained by measuring those in the primary CRC.

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Title: Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases
Authors: Hidekazu Kuramochi
Kazuhiko Hayashi
Go Nakajima
Hirotaka Kamikozuru
Masakazu Yamamoto
Kathleen D. Danenberg
Peter V. Danenberg
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Cancer Chemotherapy and Pharmacology / Issue 5/2010
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-009-1087-5

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Abstract

Purpose

Methods

Results

Conclusions

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