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Published in: Annals of Hematology 8/2021

01-08-2021 | Chronic Myeloid Leukemia | Original Article

Low-density lipoprotein (LDL) levels and risk of arterial occlusive events in chronic myeloid leukemia patients treated with nilotinib

Authors: Giovanni Caocci, Olga Mulas, Isabella Capodanno, Massimiliano Bonifacio, Mario Annunziata, Sara Galimberti, Luigiana Luciano, Mario Tiribelli, Bruno Martino, Fausto Castagnetti, Gianni Binotto, Patrizia Pregno, Fabio Stagno, Elisabetta Abruzzese, Monica Bocchia, Antonella Gozzini, Francesco Albano, Claudio Fozza, Debora Luzi, Fabio Efficace, Maria Pina Simula, Luigi Scaffidi, Claudia Baratè, Fiorenza De Gregorio, Rossella Stella, Gabriele Gugliotta, Francesca Pirillo, Malgorzata Monika Trawinska, Anna Sicuranza, Daniele Cattaneo, Immacolata Attolico, Emilia Scalzulli, Alessandra Iurlo, Robin Foà, Massimo Breccia, Giorgio La Nasa

Published in: Annals of Hematology | Issue 8/2021

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Abstract

Recommendations for dyslipidemia management aimed at reducing arterial occlusive events (AOEs) have been recently published. So far, no data have been reported on the management of dyslipidemia in chronic myeloid leukemia (CML) patients treated with nilotinib. We investigated 369 CML adult patients, stratified according to the new Systematic Coronary Risk Evaluation (SCORE) scoring system. Plasma levels of cholesterol, HDL, LDL, and triglycerides were measured prior to the start of nilotinib and after 3, 6, and 12 months. The 5-year cumulative incidence of AOEs was 15.9%. Patients with cholesterol levels > 200 mg/dL and LDL > 70 mg/dL 3 months after treatment showed a significantly higher incidence of AOEs (21.9 ± 4.6% vs 6.2 ± 2.5, P = 0.003). Patients belonging to the high and very high SCORE risk group showed a significant increase of AOEs (34.4 ± 6% vs 10 ± 2.1%, P < 0.001). In multivariate analysis, both high cholesterol and LDL levels and a high and very high SCORE risk remained significantly associated with the risk of AOEs (P = 0.008; HR = 3.5; 95% CI = 1.4–8.7 and P < 0.001; HR = 4.4; 95% CI = 2–9.8, respectively). Overall, 78 patients (21.1%) presented dyslipidemia at the time of CML diagnosis and 88 (23.3%) after starting nilotinib, but only 26 of them (29.5%) were treated with statins.
Low LDL and cholesterol plasma levels are associated with a significant lower risk of AOEs in CML patients treated with nilotinib in the real life.
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Metadata
Title
Low-density lipoprotein (LDL) levels and risk of arterial occlusive events in chronic myeloid leukemia patients treated with nilotinib
Authors
Giovanni Caocci
Olga Mulas
Isabella Capodanno
Massimiliano Bonifacio
Mario Annunziata
Sara Galimberti
Luigiana Luciano
Mario Tiribelli
Bruno Martino
Fausto Castagnetti
Gianni Binotto
Patrizia Pregno
Fabio Stagno
Elisabetta Abruzzese
Monica Bocchia
Antonella Gozzini
Francesco Albano
Claudio Fozza
Debora Luzi
Fabio Efficace
Maria Pina Simula
Luigi Scaffidi
Claudia Baratè
Fiorenza De Gregorio
Rossella Stella
Gabriele Gugliotta
Francesca Pirillo
Malgorzata Monika Trawinska
Anna Sicuranza
Daniele Cattaneo
Immacolata Attolico
Emilia Scalzulli
Alessandra Iurlo
Robin Foà
Massimo Breccia
Giorgio La Nasa
Publication date
01-08-2021
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 8/2021
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-020-04392-w

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