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Annals of Hematology
Published in: Annals of Hematology 10/2019

01-10-2019 | Lymphoma | Letter to the Editor

Addictive response of primary cutaneous diffuse large B cell lymphoma leg type to low-dose ibrutinib

Authors: Annie Pang, Rex Au-Yeung, Rock Y.Y. Leung, Yok-Lam Kwong

Published in: Annals of Hematology | Issue 10/2019

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Excerpt

Primary cutaneous diffuse large B cell lymphoma leg type (PCLBCL-LT) is a rare malignancy occurring predominantly below the knee, but may involve other cutaneous and extra-cutaneous sites [1]. Lymphoma cells typically express CD20, CD79A, BCL2, BCL6, MUM-1, and FOXP1, but not CD10 [1, 2]. Gene expression of PCLBCL-LT resembled activated B cell diffuse large B cell lymphoma (ABC-DLBCL). Consequently, genes involved in NF-κB activation were frequently mutated [3], with the MYD88 L265P mutation most prevalent, found in 60–80% of cases [3]. …
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Metadata
Title
Addictive response of primary cutaneous diffuse large B cell lymphoma leg type to low-dose ibrutinib
Authors
Annie Pang
Rex Au-Yeung
Rock Y.Y. Leung
Yok-Lam Kwong
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 10/2019
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-019-03787-8

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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