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01-05-2014

Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor

Authors: Kiyoshi Maeda, Masatsune Shibutani, Hiroshi Otani, Hisashi Nagahara, Kenji Sugano, Teturo Ikeya, Naoshi Kubo, Ryosuke Amano, Kenjiro Kimura, Kazuya Muguruma, Hiroaki Tanaka, Kosei Hirakawa

Published in: World Journal of Surgery | Issue 5/2014

Abstract

Background

We retrospectively investigated the prognostic significance of various clinicopathological factors and preoperative nutritional status to select patients with stage IV colorectal cancer (CRC) who will have a poor prognosis after palliative resection of the primary tumor.

Methods

A total of 100 stage IV CRC patients who underwent palliative resection were enrolled. Various clinicopathological factors and Onodera’s prognostic nutritional index (OPNI) were evaluated to identify any possible relationship with the prognosis.

Results

At the time of the analysis, 83 patients had died, and the median survival time was 21 months. Of the 100 patients, 24 had primary tumor-related symptoms such as obstruction or bleeding. No significant correlation was noted between the OPNI and various clinicopathological factors. The multivariate analysis of patients without primary tumor-related symptoms revealed that the OPNI was an independent prognostic factor. The overall survival of the low-OPNI group was significantly worse than that of the high-OPNI group.

Conclusions

This retrospective study suggested that patients with a low OPNI may not be candidates for palliative resection, because it provides no survival benefit to these patients.

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Title: Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor
Authors: Kiyoshi Maeda
Masatsune Shibutani
Hiroshi Otani
Hisashi Nagahara
Kenji Sugano
Teturo Ikeya
Naoshi Kubo
Ryosuke Amano
Kenjiro Kimura
Kazuya Muguruma
Hiroaki Tanaka
Kosei Hirakawa
Publication date: 01-05-2014
Publisher: Springer US
Published in: World Journal of Surgery / Issue 5/2014
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-013-2386-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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