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Published in:

01-04-2011

Diffusion-weighted Magnetic Resonance Imaging for Detecting Lymph Node Metastasis of Rectal Cancer

Authors: Yo Mizukami, Shugo Ueda, Akiyoshi Mizumoto, Tetsuro Sasada, Ryosuke Okumura, Shigene Kohno, Arimichi Takabayashi

Published in: World Journal of Surgery | Issue 4/2011

Abstract

Background

Preoperative diagnosis of lymph node metastasis is important in determining the optimal therapy for rectal cancer. It has been shown that diffusion-weighted magnetic resonance imaging (DWI) is a useful tool for detecting malignant tumors.

Methods

One hundred twenty-nine consecutive patients with rectal cancer were examined with DWI + conventional (T1-weighted and T2-weighted) MRI and computed tomography (CT). All 129 patients underwent rectal resection with total mesorectal excision. Findings on DWI + conventional MRI and CT were compared with those from histopathologic examinations.

Results

Fifty-nine (46%) patients had metastatic lymph nodes on histopathologic examinations. Two hundred twenty (18%) of 1,250 lymph nodes were pathologically positive for tumor metastasis. The overall patient-based sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of DWI + conventional MRI were 93, 81, 81, 93, and 87%, respectively. Corresponding values of CT were 73, 79, 74, 77, and 76%, respectively. The overall node-based sensitivity, specificity, PPV, NPV, and accuracy of DWI + conventional MRI were 97, 81, 52, 99, and 84%, respectively. Corresponding values of CT were 86, 80, 48, 96, and 81%, respectively.

Conclusion

DWI + conventional MRI is effective for the detection of lymph node metastasis and useful for selection of the optimal therapy for rectal cancer.

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Title: Diffusion-weighted Magnetic Resonance Imaging for Detecting Lymph Node Metastasis of Rectal Cancer
Authors: Yo Mizukami
Shugo Ueda
Akiyoshi Mizumoto
Tetsuro Sasada
Ryosuke Okumura
Shigene Kohno
Arimichi Takabayashi
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 4/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-011-0986-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diffusion-weighted Magnetic Resonance Imaging for Detecting Lymph Node Metastasis of Rectal Cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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