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Published in:

01-12-2010

Safety of Liver Resections in Obese and Overweight Patients

Authors: Silvio Balzan, Ganesh Nagarajan, Olivier Farges, Claudio Zettler Galleano, Safi Dokmak, Catherine Paugam, Jacques Belghiti

Published in: World Journal of Surgery | Issue 12/2010

Abstract

Background

The new global epidemic, overweight and obesity, has a significant role in the etiology of liver tumors. However, the impact of body weight on the outcome after liver resection is unknown.

Methods

We carried out a prospective study of 684 patients who underwent liver resections. Patients were stratified according their body mass index (BMI) as follows: normal (<25 kg/m²) (52%), overweight (25–29 kg/m²) (34%), and obese (≥30 kg/m²) (14%), and according to the extent of resection, as either minor or major hepatectomy. Preoperative and intraoperative characteristics and outcomes were prospectively studied. The Dindo–Clavien classification of morbidity was used.

Results

Overall postoperative morbidity and morbidity rates were not influenced by BMI. Pulmonary complications were significantly more frequent in obese patients irrespective of the extent of resection. During major resection obese had longer pedicular clamping and more frequently required blood transfusion. After major resection, major morbidity (Dindo–Clavien grade III or more) was more frequent in obese (57%) and overweight (54%) patients than in patients of normal body weight (35%; P < 0.05), including a higher rate of respiratory complications and ascites and longer intensive care unit (ICU) and hospital stays. Obesity and overweight were independent predictors of major morbidity (OR 2.6, 95% CI 1.2–5.8 and OR 1.9, 95% CI 1.2–3.2, respectively), and obesity was a predictor of the need for blood transfusion (OR 3.3, 95% CI 1.4–7.9) after major resections.

Conclusions

Obese and overweight patients are at increased risk of potentially life-threatening morbidity after major hepatic resections. Because the risk of mortality is not increased significantly, there is no justification for a compromise in the indication or extent of surgery.

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Title: Safety of Liver Resections in Obese and Overweight Patients
Authors: Silvio Balzan
Ganesh Nagarajan
Olivier Farges
Claudio Zettler Galleano
Safi Dokmak
Catherine Paugam
Jacques Belghiti
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 12/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0756-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Safety of Liver Resections in Obese and Overweight Patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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