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World Journal of Surgery

Published in:

01-08-2008

Liver Transplantation: The Last Measure in the Treatment of Bile Duct Injuries

Authors: Eduardo de Santibañes, Victoria Ardiles, Adrian Gadano, Martin Palavecino, Juan Pekolj, Miguel Ciardullo

Published in: World Journal of Surgery | Issue 8/2008

Abstract

Background

Bile duct injury (BDI) is a severe complication that may arise during the surgical treatment of a benign disease. A significant proportion of cases develop end-stage liver disease and a liver transplant is required. The aim of this study was to analyze the indications and results of liver transplantation as treatment for BDI.

Methods

Between January 1988 and May 2007, 20 patients with end-stage liver disease secondary to BDI were included on the liver transplant waiting list. Retrospective charts were analyzed and survival was estimated by the Kaplan–Meier test.

Results

Four patients died while on the waiting list and 16 received a transplant. Injury to the bile duct occurred during a cholecystectomy in 13 of 16 patients, with the main cause of the lesion being duct division in six patients and resection in four. All patients had received some surgical treatment (median = 2 procedures) before being considered for a transplant. The liver transplant came from a cadaveric donor for all patients and the median time between BDI and liver transplant was 60 months. Two patients died in the postoperative period and nine had complications. Three patients died in the late postoperative period. Median follow-up was 62 (range = 24–152) months. One-, three-, and five-year survival rates were 81, 75, and 75%, respectively.

Conclusion

Complex bile duct injuries and bile duct injuries with previous repair attempts can result in end-stage liver disease. In these cases, liver transplantation provides long-term survival.

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Title: Liver Transplantation: The Last Measure in the Treatment of Bile Duct Injuries
Authors: Eduardo de Santibañes
Victoria Ardiles
Adrian Gadano
Martin Palavecino
Juan Pekolj
Miguel Ciardullo
Publication date: 01-08-2008
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 8/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-008-9650-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liver Transplantation: The Last Measure in the Treatment of Bile Duct Injuries

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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