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01-08-2008

Biological Behavior and Prognosis of Encapsulated Papillary Carcinoma of the Thyroid: Experience of a Japanese Hospital for Thyroid Care

Authors: Yasuhiro Ito, Mitsuyoshi Hirokawa, Takashi Uruno, Minoru Kihara, Takuya Higashiyama, Yuuki Takamura, Akihiro Miya, Kaoru Kobayashi, Fumio Matsuzuka, Akira Miyauchi

Published in: World Journal of Surgery | Issue 8/2008

Abstract

Aims

A subtype of papillary thyroid carcinoma that is totally surrounded by a fibrous capsule is designated an encapsulated carcinoma. In this study, we investigated the biologic behavior and prognosis of this type of carcinoma.

Methods

The clinicopathologic parameters and prognosis were compared between 1207 patients with conventional papillary carcinoma and 149 patients diagnosed as having encapsulated papillary carcinoma who underwent initial surgery between 1987 and 1996.

Results

Sex, age, and the tumor size of the encapsulated carcinoma did not differ from those of patients with conventional papillary carcinoma. However, none of the patients with encapsulated carcinoma showed distant metastasis at diagnosis. The incidences of pathologic lymph node metastasis and clinically apparent lateral node metastasis in patients with encapsulated carcinomas were significantly lower than in those with a conventional papillary carcinoma. Ten patients (6.7%) with encapsulated carcinoma showed recurrence after surgery. After excluding recurrence to the remnant thyroid, disease-free survival of patients with encapsulated carcinoma was significantly better than that of those with conventional papillary carcinoma. None of the patients with encapsulated carcinoma died of carcinoma.

Conclusion

Encapsulated papillary carcinoma exhibits a more indolent biologic behavior than conventional papillary carcinoma. However, because recurrence to locoregional and even distant organs can be seen, careful and constant postoperative follow-up is recommended.

Sobin LH, Wittekind C, (eds) (2002) UICC: TNM Classification of Malignant Tumors, 6th edn. Wiley-Liss, New York

Ito Y, Miyauchi A, Jikuzono T et al (2007) Risk factors contributing to a poor prognosis of papillary thyroid carcinoma; validity of UICC/AJCC TNM classification and stage grouping. World J Surg 31:838–848PubMedCrossRef

Ito Y, Tomoda C, Uruno T et al (2006) Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival. World J Surg 30:780–786PubMedCrossRef

Ito Y, Tomoda C, Uruno T et al (2005) Ultrasound-detectable and anatomopathologically detectable node metastasis in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma. World J Surg 29:917–920PubMedCrossRef

Johnson TL, Lloyd RV, Thompson NW et al (1988) Prognostic implications of the tall cell variant of papillary thyroid carcinoma. Am J Surg Pathol 12:22–27PubMedCrossRef

Egea AM, Gonzales JMR, Perez JS et al (1993) Prognostic value of the tall cell variety of papillary cancer of the thyroid. Eur J Surg Oncol 19:517–521

Wenig BM, Thomson LDR, Adair CF et al (1998) Thyroid papillary carcinoma of columnar cell type; a clinicopathologic study of 16 cases. Cancer 82:40–53CrossRef

Sakamoto A, Kasai N, Sugano H (1983) Poorly differentiated carcinoma of the thyroid: a clinicopathologic entity for a high risk group of papillary and follicular carcinomas. Cancer 52:1849–1855PubMedCrossRef

Sakamoto A (2004) Definition of poorly differentiated carcinoma of the thyroid: the Japanese experience. Endocr Pathol 15:307–311PubMedCrossRef

10.

Ito Y, Hirokawa M, Uruno T et al (2008) Prevalence and biological behavior of papillary thyroid carcinoma; experience at a single hospital. Pathology (in press)

11.

Carcangiue ML, Zampi G, Pupi A et al (1985) Papillary carcinoma of the thyroid: a clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer 55:805–828CrossRef

12.

Schroder S, Bockere W, Dralle H et al (1984) The encapsulated papillary carcinoma of the thyroid: a morphological subtype of papillary thyroid carcinoma. Cancer 54:90–93PubMedCrossRef

13.

Moreno A, Rodriguez JM, Sola J et al (1996) Encapsulated papillary neoplasm of the thyroid: retrospective clinicopathological study with long term follow up. Eur J Surg 162:177–180PubMed

14.

LiVolsi VA, Mazzaferri EL, Albores-Saavedra J et al (2004) Papillary carcinoma. In: DeLeillis RA, Lloyd RV, Heitz PU et al (eds), Pathology and Genetics of Tumours of Endocrine Organs. IARC Press, Lyon, pp 57–66

15.

Rosai J, Carcangiu ML, Delellis RA (1992). Atlas of Tumor Pathology. Tumors of the Thyroid Gland. AFIP, Washington, DC, p 100

16.

Miyauchi A, Matsusaka K, Kihara M et al (1998) The role of ansa-to-recurrent-laryngeal nerve anastomosis in operations for thyroid cancer. Eur J Surg 164:927–933PubMedCrossRef

17.

Miyauchi A, Yokozawa T, Kobayashi K et al (2001) Opposite ansa cervicalis to recurrent laryngeal nerve anastomosis to restore phonation in patients with advanced thyroid cancer. Eur J Surg 167:540–541PubMedCrossRef

18.

Chan JKC (1990) Papillary carcinoma of thyroid: classical and variants. Histol Histopathol 5:241–257PubMed

19.

Ito Y, Higashiyama T, Takamura Y et al (2007) Risk factors for recurrence to the lymph node in papillary thyroid carcinoma patients without preoperatively detectable lateral node metastasis: validity of prophylactic modified radical neck dissection. World J Surg 31:2085–2091PubMedCrossRef

20.

Ito Y, Higashiyama T, Takamura Y et al (2007) Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules. Anticancer Res 27:2243–2246

Title: Biological Behavior and Prognosis of Encapsulated Papillary Carcinoma of the Thyroid: Experience of a Japanese Hospital for Thyroid Care
Authors: Yasuhiro Ito
Mitsuyoshi Hirokawa
Takashi Uruno
Minoru Kihara
Takuya Higashiyama
Yuuki Takamura
Akihiro Miya
Kaoru Kobayashi
Fumio Matsuzuka
Akira Miyauchi
Publication date: 01-08-2008
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 8/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-008-9482-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Biological Behavior and Prognosis of Encapsulated Papillary Carcinoma of the Thyroid: Experience of a Japanese Hospital for Thyroid Care

Abstract

Aims

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aims

Methods

Results

Conclusion

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