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01-12-2007

Minimally Invasive Ablative Therapies for Invasive Breast Carcinomas: An Overview of Current Literature

Authors: Stijn van Esser, Maurice A. A. J. van den Bosch, Paul J. van Diest, Willem Th. M. Mali, Inne H. M. Borel Rinkes, Richard van Hillegersberg

Published in: World Journal of Surgery | Issue 12/2007

Abstract

Background

Minimally invasive treatment may be an alternative to breast-conserving surgery.

Methods

A structured PubMed, Embase, Cochrane, and Web of Science search was performed. Endpoints studied were feasibility, completeness of ablation, timing of the sentinel node biopsy (SNB), imaging modalities, and treatment-related complications.

Results

A total of 24 articles were retrieved, and the level of evidence varied (2B-4). Mainly phase II studies with a treat-and-resect protocol were analyzed. Up to 100% completeness of ablation was reported for radiofrequency ablation (RFA), cryosurgery, and focused ultrasound (FUS). The oncologic results need further evaluation. Dynamic contrast enhanced MRI seems to be the best method for monitoring treatment response (77% sensitivity, 100% specificity). Ultrasound is suitable for guiding probes into the tumor. There is no consensus on the timing of the SNB.

Conclusions

All studies on minimally invasive ablative modalities published so far show that these techniques are feasible and safe. At this stage only T1 tumors should be ablated in a clinical trial setting; it is unclear which of the modalities is most suitable.

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Title: Minimally Invasive Ablative Therapies for Invasive Breast Carcinomas: An Overview of Current Literature
Authors: Stijn van Esser
Maurice A. A. J. van den Bosch
Paul J. van Diest
Willem Th. M. Mali
Inne H. M. Borel Rinkes
Richard van Hillegersberg
Publication date: 01-12-2007
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 12/2007
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-007-9278-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Minimally Invasive Ablative Therapies for Invasive Breast Carcinomas: An Overview of Current Literature

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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