The apple core sign was originally described on barium enemas as an ab rupt, irregular, and segmental stenosis with “shouldered margins” in colonic wall [1‐3]. This sign represents a non-distensible narrowing of the intestinal lumen by a stenosing circumferential colorectal cancer that allows passage of only a small amount of contrast media. The appearance is similar to an apple core, that is, the remnant of a partially eaten apple (Fig. 1). The apple core sign is also known as “napkin ring sign” [1, 2].
FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognise FND and what are the treatment options?
Watch it live: Monday 20 October 2025, 18:00-19:00 (CEST)
PET imaging is playing an increasingly critical role in managing AD. Our expert-led program will empower you with practical strategies and real-world case studies to effectively integrate it into clinical practice.
This content is intended for healthcare professionals outside of the UK.
The global burden of ALD is growing and compounded by frequent late-stage diagnosis and undertreatment. Get the latest insights into patient risk and identification, treatment and management, and the arrival of MetALD.
Watch it live: 19 November 2025, 18:00-19:30 (CET)