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Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2018

01-03-2018 | Editorial Commentary

Is the whole larger than the sum of the parts? Integrated PET/MRI as a tool for response prediction

Author: Felix M. Mottaghy

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2018

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Excerpt

Several combinations of hybrid imaging have been evaluated in the last two decades [1]. From the beginning, it was clear that the combination of nuclear molecular imaging by means of PET or SPECT combined with contrast-enhanced computed tomography added a significant aspect on the sensitivity and specificity as well as the accuracy of the combined integrated methods compared to the side-by-side reading [2, 3]. …
Literature
2.
go back to reference Cohade C, Osman M, Leal J, Wahl RL. Direct comparison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma. J Nucl Med. 2003;44:1797–803.PubMed Cohade C, Osman M, Leal J, Wahl RL. Direct comparison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma. J Nucl Med. 2003;44:1797–803.PubMed
4.
go back to reference Som P, Atkins HL, Bandoypadhyay D, Fowler JS, MacGregor RR, Matsui K, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-d-glucose (F-18): Nontoxic tracer for rapid tumor detection. J Nucl Med. 1980;21:670–5.PubMed Som P, Atkins HL, Bandoypadhyay D, Fowler JS, MacGregor RR, Matsui K, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-d-glucose (F-18): Nontoxic tracer for rapid tumor detection. J Nucl Med. 1980;21:670–5.PubMed
5.
go back to reference Kuhl DE, Phelps ME, Hoffman EJ, Robinson GD Jr, MacDonald NS. Initial clinical experience with 18F-2-fluoro-2-deoxy-d-glucose for determination of local cerebral glucose utilization by emission computed tomography. Acta Neurol Scand Suppl. 1977;64:192–3.PubMed Kuhl DE, Phelps ME, Hoffman EJ, Robinson GD Jr, MacDonald NS. Initial clinical experience with 18F-2-fluoro-2-deoxy-d-glucose for determination of local cerebral glucose utilization by emission computed tomography. Acta Neurol Scand Suppl. 1977;64:192–3.PubMed
6.
go back to reference Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, et al. Measurement of local cerebral glucose metabolism in man with 18F-2-fluoro-2-deoxy-d-glucose. Acta Neurol Scand Suppl. 1977;64:190–1.PubMed Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, et al. Measurement of local cerebral glucose metabolism in man with 18F-2-fluoro-2-deoxy-d-glucose. Acta Neurol Scand Suppl. 1977;64:190–1.PubMed
13.
go back to reference Minn H, Soini I. [18F]fluorodeoxyglucose scintigraphy in diagnosis and follow up of treatment in advanced breast cancer. Eur J Nucl Med. 1989;15:61–6.CrossRefPubMed Minn H, Soini I. [18F]fluorodeoxyglucose scintigraphy in diagnosis and follow up of treatment in advanced breast cancer. Eur J Nucl Med. 1989;15:61–6.CrossRefPubMed
16.
go back to reference Goorts B, Voo S, van Nijnatten TJA, Kooreman LFS, de Boer M, Keymeulen K, et al. Hybrid (18)F-FDG PET/MRI might improve locoregional staging of breast cancer patients prior to neoadjuvant chemotherapy. Eur J Nucl Med Mol Imaging. 2017. https://doi.org/10.1007/s00259-017-3745-x. Goorts B, Voo S, van Nijnatten TJA, Kooreman LFS, de Boer M, Keymeulen K, et al. Hybrid (18)F-FDG PET/MRI might improve locoregional staging of breast cancer patients prior to neoadjuvant chemotherapy. Eur J Nucl Med Mol Imaging. 2017. https://​doi.​org/​10.​1007/​s00259-017-3745-x.
17.
go back to reference van Nijnatten TJA, Goorts B, Voo S, de Boer M, Kooreman LFS, Heuts EM, et al. Added value of dedicated axillary hybrid 18F-FDG PET/MRI for improved axillary nodal staging in clinically node-positive breast cancer patients: A feasibility study. Eur J Nucl Med Mol Imaging. 2017. https://doi.org/10.1007/s00259-017-3823-0. van Nijnatten TJA, Goorts B, Voo S, de Boer M, Kooreman LFS, Heuts EM, et al. Added value of dedicated axillary hybrid 18F-FDG PET/MRI for improved axillary nodal staging in clinically node-positive breast cancer patients: A feasibility study. Eur J Nucl Med Mol Imaging. 2017. https://​doi.​org/​10.​1007/​s00259-017-3823-0.
19.
go back to reference Dose Schwarz J, Bader M, Jenicke L, Hemminger G, Janicke F, Avril N. Early prediction of response to chemotherapy in metastatic breast cancer using sequential 18F-FDG PET. J Nucl Med. 2005;46:1144–50.PubMed Dose Schwarz J, Bader M, Jenicke L, Hemminger G, Janicke F, Avril N. Early prediction of response to chemotherapy in metastatic breast cancer using sequential 18F-FDG PET. J Nucl Med. 2005;46:1144–50.PubMed
21.
go back to reference Dietzel M, Kaiser C, Pinker K, Wenkel E, Hammon M, Uder M, et al. Automated semi-quantitative analysis of breast MRI: Potential imaging biomarker for the prediction of tissue response to neoadjuvant chemotherapy. Breast Care (Basel). 2017;12:231–6. https://doi.org/10.1159/000480226.CrossRef Dietzel M, Kaiser C, Pinker K, Wenkel E, Hammon M, Uder M, et al. Automated semi-quantitative analysis of breast MRI: Potential imaging biomarker for the prediction of tissue response to neoadjuvant chemotherapy. Breast Care (Basel). 2017;12:231–6. https://​doi.​org/​10.​1159/​000480226.CrossRef
Metadata
Title
Is the whole larger than the sum of the parts? Integrated PET/MRI as a tool for response prediction
Author
Felix M. Mottaghy
Publication date
01-03-2018
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2018
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-017-3908-9

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