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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2007

01-09-2007 | Original article

Direct comparison of [18F]FDG PET/CT with PET alone and with side-by-side PET and CT in patients with malignant melanoma

Authors: Felix M. Mottaghy, Cord Sunderkötter, Roland Schubert, Petra Wohlfart, Norbert M. Blumstein, Bernd Neumaier, Gerhard Glatting, Cueneyt Özdemir, Andreas K. Buck, Karin Scharfetter-Kochanek, Sven N. Reske

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2007

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Abstract

Purpose

The purpose of this retrospective, blinded study was to evaluate the additional value of [18F]FDG PET/CT in comparison with PET alone and with side-by-side PET and CT in patients with malignant melanoma (MM).

Methods

A total of 127 consecutive studies of patients with known MM referred for a whole-body PET/CT examination were included in this study. PET alone, side-by-side PET and CT and integrated PET/CT study were independently and separately interpreted without awareness of the clinical information. One score each was applied for certainty of lesion localisation and for certainty of lesion characterisation. Verification of the findings was subsequently performed using all available clinical, pathological (n = 30) and follow-up information.

Results

The number of lesions with an uncertain localisation was significantly (p < 0.001) reduced by PET/CT and side-by-side PET and CT (p < 0.05) in comparison with PET alone. In line with this increase in certainty integrated PET/CT reading also improved certainty in characterisation of lesions, however, this did not reach significance (p = 0.057) compared versus PET alone. Respectively, PET, side-by-side PET and CT and PET/CT showed a sensitivity of 86%, 89% and 91%, a specificity of 94%, 94% and 94%, a positive predictive value of 96%, 96% and 96% and a negative predictive value of 80%, 83% and 87%.

Conclusion

Integrated PET/CT offers a significant benefit in lesion localisation and an improvement in lesion characterisation compared with PET alone or with side-by-side PET and CT. The benefit is not as great as that reported for other tumour entities, which may be due to the high avidity of MM for [18F]FDG.
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Metadata
Title
Direct comparison of [18F]FDG PET/CT with PET alone and with side-by-side PET and CT in patients with malignant melanoma
Authors
Felix M. Mottaghy
Cord Sunderkötter
Roland Schubert
Petra Wohlfart
Norbert M. Blumstein
Bernd Neumaier
Gerhard Glatting
Cueneyt Özdemir
Andreas K. Buck
Karin Scharfetter-Kochanek
Sven N. Reske
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2007
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-006-0358-1

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