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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-08-2011 | Original Article

Calibration of gamma camera systems for a multicentre European ¹²³I-FP-CIT SPECT normal database

Authors: Livia Tossici-Bolt, John C. Dickson, Terez Sera, Robin de Nijs, Maria Claudia Bagnara, Catherine Jonsson, Egon Scheepers, Felicia Zito, Anita Seese, Pierre Malick Koulibaly, Ozlem L. Kapucu, Michel Koole, Maria Raith, Jean George, Markus Nowak Lonsdale, Wolfgang Münzing, Klaus Tatsch, Andrea Varrone

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2011

Abstract

Purpose

A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [¹²³I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization and harmonization of the imaging equipment of the institutions involved.

Methods

¹²³I SPECT images of a striatal phantom filled with striatal to background ratios between 10:1 and 1:1 were acquired on all the gamma cameras with absolute ratios measured from aliquots. The images were reconstructed by a core lab using ordered subset expectation maximization (OSEM) without corrections (NC), with attenuation correction only (AC) and additional scatter and septal penetration correction (ACSC) using the triple energy window method. A quantitative parameter, the simulated specific binding ratio (sSBR), was measured using the “Southampton” methodology that accounts for the partial volume effect and compared against the actual values obtained from the aliquots. Camera-specific recovery coefficients were derived from linear regression and the error of the measurements was evaluated using the coefficient of variation (COV).

Results

The relationship between measured and actual sSBRs was linear across all systems. Variability was observed between different manufacturers and, to a lesser extent, between cameras of the same type. The NC and AC measurements were found to underestimate systematically the actual sSBRs, while the ACSC measurements resulted in recovery coefficients close to 100% for all cameras (AC range 69–89%, ACSC range 87–116%). The COV improved from 46% (NC) to 32% (AC) and to 14% (ACSC) (p < 0.001).

Conclusion

A satisfactory linear response was observed across all cameras. Quantitative measurements depend upon the characteristics of the SPECT systems and their calibration is a necessary prerequisite for data pooling. Together with accounting for partial volume, the correction for scatter and septal penetration is essential for accurate quantification.

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Title: Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database
Authors: Livia Tossici-Bolt
John C. Dickson
Terez Sera
Robin de Nijs
Maria Claudia Bagnara
Catherine Jonsson
Egon Scheepers
Felicia Zito
Anita Seese
Pierre Malick Koulibaly
Ozlem L. Kapucu
Michel Koole
Maria Raith
Jean George
Markus Nowak Lonsdale
Wolfgang Münzing
Klaus Tatsch
Andrea Varrone
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1801-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Calibration of gamma camera systems for a multicentre European ¹²³I-FP-CIT SPECT normal database

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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