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European Journal of Nuclear Medicine and Molecular Imaging

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01-10-2006 | Original article

Human radiation dosimetry of [¹¹C]MeAIB, a new tracer for imaging of system A amino acid transport

Authors: Tuula Tolvanen, Kjell Någren, Meixiang Yu, Eija Sutinen, Katja Havu-Aurén, Sirkku Jyrkkiö, Markku Asola, Eira Kotoneva, Pirjo Nuutila, Heikki Minn

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2006

Abstract

Purpose

[N-methyl-¹¹C]α-methylaminoisobutyric acid ([¹¹C]MeAIB) is a promising positron emission tomography (PET) tracer for imaging hormonally regulated system A amino acid transport. Uptake of [¹¹C]MeAIB is totally specific for amino acid transport since [¹¹C]MeAIB is metabolically stable both extra- and intracellularly. The aim of this study was to measure cumulated radioactivity in different organs and estimate the absorbed radiation doses to humans with the Medical Internal Radiation Dosimetry (MIRD) method.

Methods

Radiation absorbed doses were calculated from PET images for 25 volunteers. Dynamic acquisition data were obtained for the thoracic, abdominal, femoral and head and neck regions. The median dose of intravenously injected [¹¹C]MeAIB was 422±35 MBq, with a range of 295–493 MBq. After PET imaging the radioactivity in voided urine was measured. Experimental human data were used for residence time estimates. Radiation doses were calculated with commonly used software.

Results

The effective dose for a 70-kg adult was 0.004 mSv/MBq, corresponding to a 1.72 mSv effective dose from the PET study with injection of 430 MBq [¹¹C]MeAIB. The highest absorbed doses were in the pancreas (0.018 mGy/MBq), kidneys (0.017 mGy/MBq), intestine (0.014 mGy/MBq), liver (0.008 mGy/MBq) and stomach (0.005 mGy/MBq). Only 0.57% of injected activity was excreted to urine within 1 h after injection.

Conclusion

Biodistribution of [¹¹C]MeAIB in the abdominal region reflected the high activity of the transportation of amino acids via system A and these organs also had the highest radiation doses. An effective dose of 0.004 mSv/MBq is fully justified when [¹¹C]MeAIB PET is performed to study system A activity in vivo.

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Title: Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport
Authors: Tuula Tolvanen
Kjell Någren
Meixiang Yu
Eija Sutinen
Katja Havu-Aurén
Sirkku Jyrkkiö
Markku Asola
Eira Kotoneva
Pirjo Nuutila
Heikki Minn
Publication date: 01-10-2006
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2006
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0096-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Human radiation dosimetry of [¹¹C]MeAIB, a new tracer for imaging of system A amino acid transport

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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