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Skeletal Radiology
Published in: Skeletal Radiology 1/2011

01-01-2011 | Scientific Article

Matrix-induced autologous chondrocyte implantation of the knee: mid-term and long-term follow-up by MR arthrography

Authors: Eugenio Genovese, Mario Ronga, Maria Gloria Angeretti, Raffaele Novario, Anna Leonardi, Mauro Albrizio, Leonardo Callegari, Carlo Fugazzola

Published in: Skeletal Radiology | Issue 1/2011

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Abstract

Objective

To define magnetic resonance (MR) arthrography imaging findings of matrix-induced autologous chondrocyte implantation (MACI) grafts of the knee in order to describe implant behaviour and to compare findings with validated clinical scores 30 and 60 months after MACI implant.

Materials and methods

Thirteen patients were recruited (10 male, 3 female) with a total number of 15 chondral lesions. Each patient underwent an MACI procedure and MR arthrography 30 and 60 months after surgery. MR arthrography was performed using a dedicated coil with a 1.5-Tesla unit. The status of the chondral implant was evaluated with the modified MOCART scoring scale. The lining of the implant, the integration to the border zone, the surface and structure of the repaired tissue were assessed, and the presence of bone marrow oedema and effusion was evaluated. For clinical assessment, the Cincinnati score was used.

Results

At 60 months, the abnormality showed worsening in 1 out of 15 cases. Integration showed improvement in 3 out of 15 cases, and worsening in 3 out of 15 cases. Two surfaces of the implant showed further deterioration at 60 months, and 1 afflicted implant fully recovered after the same time interval. Implant contrast enhancement at 30 months was seen in 2 out of 15 cases, 1 of which recovered at 60 months. According to the MOCART score, 4 cases were rated 68.4 out of 75 at 30 months and 65 out of 75 at 60 months. The mean clinical score decreased from 8.6 out of 10 at 30 months to 8.1 out of 10 at 60 months.

Conclusion

Magnetic resonance arthrography improved the evaluation of implants and facilitated the characterisation of MACI integration with contiguous tissues. The follow-up showed significant changes in MACI, even at 60 months, allowing for useful long-term MR evaluations.
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Metadata
Title
Matrix-induced autologous chondrocyte implantation of the knee: mid-term and long-term follow-up by MR arthrography
Authors
Eugenio Genovese
Mario Ronga
Maria Gloria Angeretti
Raffaele Novario
Anna Leonardi
Mauro Albrizio
Leonardo Callegari
Carlo Fugazzola
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 1/2011
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-010-0939-8

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