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01-07-2012 | Pictorial Essay

Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation

Authors: Arthur B. Meyers, Alexander J. Towbin, James I. Geller, Daniel J. Podberesky

Published in: Pediatric Radiology | Issue 7/2012

Abstract

Gadoxetate disodium (Gd-EOB-DTPA) is a hepatobiliary MRI contrast agent widely used in adults for characterization of liver tumors and increasingly used in children. Hepatoblastoma is the most common primary hepatic malignancy of childhood. In this review, we describe our experience with this agent both before and after initiating therapy in children with hepatoblastoma.

Ringe KI, Husarik DB, Sirlin CB et al (2010) Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR 195:13–28PubMedCrossRef

Cruite I, Schroeder M, Merkle EM et al (2010) Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR 195:29–41PubMedCrossRef

Meyers AM, Towbin AJ, Serai A et al (2011) Characterization of pediatric liver lesions with gadoxetate disodium. Pediatr Radiol 41:1183–1197PubMedCrossRef

Zech CJ, Herrmann KA, Reiser MF et al (2007) MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. Magn Reson Med Sci 6:43–52PubMedCrossRef

Choi JY, Kim MJ, Park YM et al (2011) Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics. AJR 197:399–405PubMedCrossRef

Goodwin MD, Dobson JE, Sirlin CB et al (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents. Radiographics 31:1547–1568CrossRef

Vasanawala S (2010) MRI of the liver—how to do it. Pediatr Radiol 40:431–437PubMedCrossRef

Marrone G, Maggiore G, Carollo V et al (2011) Biliary cystadenoma with bile duct communication depicted on liver-specific contrast agent-enhanced MRI in a child. Pediatr Radiol 41:121–124PubMedCrossRef

Tamrazi A, Vasanawala SS (2011) Functional hepatobiliary MR imaging in children. Pediatr Radiol 22:1250–1258CrossRef

10.

Das CJ, Dhingra S, Gupta AK et al (2009) Imaging of paediatric liver tumours with pathological correlation. Clin Radiol 64:1015–1025PubMedCrossRef

11.

Imbach P (2006) Hepatic tumors. In: Imbach P, Kuhne T, Arceci RJ (eds) Pediatric oncology: a comprehensive guide. Springer, New York, pp 187–191CrossRef

12.

Chung EM, Lattin GE, Cube R et al (2011) Pediatric liver masses: radiologic-pathologic correlation part 2. Malignant tumors. Radiographics 31:483–507PubMedCrossRef

13.

Roebuck DJ, Aronson D, Clapuyt P et al (2005) PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol 37:123–132CrossRef

14.

Vogel TJ, Kummel S, Hammerstingl R et al (1996) Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 200:59–67

15.

Reimer P, Rummeny EJ, Shamsi K et al (1996) Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 199:177–183PubMed

16.

Towbin AJ, Luo GG, Yin H et al (2010) Focal nodular hyperplasia in children, adolescents, and young adults. Pediatr Radiol 41:341–349PubMedCrossRef

17.

Asbach P, Klessen C, Koch M et al (2007) Magnetic resonance imaging findings of atypical focal nodular hyperplasia of the liver. Clin Imaging 31:244–252PubMedCrossRef

18.

Christison-Lagay ER, Burrows PE, Alomari A et al (2007) Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 42:62–67PubMedCrossRef

19.

Goshima S, Kanematsu M, Watanabe H et al (2010) Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI. AJR 195:941–946PubMedCrossRef

20.

Prokurat A, Kluge P, Kosciesza A et al (2002) Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 39:510–518PubMedCrossRef

Title: Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation
Authors: Arthur B. Meyers
Alexander J. Towbin
James I. Geller
Daniel J. Podberesky
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-012-2366-6

2024 ASCO Annual Meeting

Springer Medicine

Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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