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01-07-2012 | Original Article

Contrast-enhanced sonography of malignant pediatric abdominal and pelvic solid tumors: preliminary safety and feasibility data

Authors: M. Beth McCarville, Sue C. Kaste, Fredric A. Hoffer, Raja B. Khan, R. Christopher Walton, Bruce S. Alpert, Wayne L. Furman, Chenghong Li, Xiaoping Xiong

Published in: Pediatric Radiology | Issue 7/2012

Abstract

Background

Little information exists regarding pediatric contrast-enhanced US.

Objective

To assess the safety and feasibility of contrast-enhanced US of pediatric abdominal and pelvic tumors.

Materials and methods

This prospective study included eight boys and five girls (mean age, 10.8 years) with abdominal or pelvic tumors. Cohorts of three subjects underwent US with perflutren contrast agent at escalating dose levels. Neurological and funduscopic examination, electrocardiography and continuous pulse oximetry were performed before and after contrast administration. Three radiologists independently scored six imaging parameters on pre- and postcontrast sonography. Inter-reviewer agreement was measured by the Kappa statistic.

Results

No neurological, retinal, electrocardiographical or pulse oximetry changes were attributable to the contrast agent. Two subjects reported minor, transient symptoms. Postcontrast US parameter scores improved slightly in 8 of 12 subjects. Postcontrast ultrasound inter-reviewer agreement improved slightly for detection of tumor margins (precontrast = 0.20, postcontrast = 0.26), local tumor invasion (precontrast = -0.01, postcontrast = 0.10) and adenopathy (precontrast = 0.35, postcontrast = 0.44).

Conclusions

Although our sample size is small, perflutren contrast agents appear to be safe and well tolerated in children. Contrast-enhanced sonography of pediatric abdominal and pelvic tumors is feasible, but larger studies are needed to define their safety and efficacy in children.

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Title: Contrast-enhanced sonography of malignant pediatric abdominal and pelvic solid tumors: preliminary safety and feasibility data
Authors: M. Beth McCarville
Sue C. Kaste
Fredric A. Hoffer
Raja B. Khan
R. Christopher Walton
Bruce S. Alpert
Wayne L. Furman
Chenghong Li
Xiaoping Xiong
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-011-2338-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Contrast-enhanced sonography of malignant pediatric abdominal and pelvic solid tumors: preliminary safety and feasibility data

Abstract

Background

Objective

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusions

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