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Published in:

01-08-2012 | Riley Symposium

Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease

Authors: Joshua W. Vincentz, Michael Rubart, Anthony B. Firulli

Published in: Pediatric Cardiology | Issue 6/2012

Abstract

The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the Hand1 sympathetic neuron-specific cis-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed.

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Title: Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease
Authors: Joshua W. Vincentz
Michael Rubart
Anthony B. Firulli
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 6/2012
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-012-0248-1

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