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01-12-2009 | Original Paper

Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?

Authors: Marcin Słojewski, Bogusław Czerny, Krzysztof Safranow, Marek Droździk, Andrzej Pawlik, Katarzyna Jakubowska, Maria Olszewska, Adam Gołąb, Elżbieta Byra, Dariusz Chlubek, Andrzej Sikorski

Published in: Urolithiasis | Issue 6/2009

Abstract

The role of particular elements in lithogenesis is still unclear and debated. Probably some of them may promote or conversely inhibit crystal nucleation of organic or mineral species. A few epidemiological data link smoking with the risk of calcium stones. The aim of this hospital-based study was to evaluate the distribution of trace elements in urine and urinary stones, and possible correlation with stone constituents in smoking and non-smoking individuals. 209 stones and urine samples collected from idiopathic stone-formers were analyzed to evaluate the mineral composition and the distribution of elements, 29 in stones and 21 in urine. Values were statistically compared considering smoking, arterial hypertension and coronary heart disease as grouping variables. No differences were noted either for comparison of mineral components or the elements concentrations in stones in both groups. The concentration of mercury in urine was higher in smokers than in non-smokers, but the statistical significance was at the moderate level. Our findings do not support the concept of possible association between smoking and urinary lithogenesis, but we believe that further investigations are needed in this area.

Ramello A, Vitale C, Marangella M (2000) Epidemiology of nephrolithiasis. J Nephrol 13(Suppl. 3):45–50

Trinchieri A, Castelnuovo C, Lizzano R, Zanetti G (2005) Calcium stone disease: a multiform reality. Urol Res 33:194–198. doi:10.1007/s00240-004-0459-x CrossRefPubMed

Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–344. doi:10.1016/S0140-6736(06)68071-9 CrossRefPubMed

Daudon M, Bazin D, André G, Jungers P, Cousson A, Chevallier P, Véron E, Matzen G (2009) Examination of whewellite kidney stones by scanning electron microscopy and powder neutron diffraction techniques. J Appl Crystallogr 42:109–115. doi:10.1107/S0021889808041277 CrossRef

Daudon M, Jungers P, Bazin D (2008) Peculiar morphology of stones in primary hyperoxaluria. N Engl J Med. 359:100–102. doi:10.1056/NEJMc0800990 CrossRefPubMed

Atakan IH, Kaplan M, Seren G, Aktoz T, Gül H, Inci O (2007) Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients. Int Urol Nephrol 39:351–356. doi:10.1007/s11255-006-9050-4 CrossRefPubMed

Bazin D, Chevallier P, Matzen G, Jungers P, Daudon M (2007) Heavy elements in urinary stones. Urol Res 35:179–184. doi:10.1007/s00240-007-0099-z CrossRefPubMed

Joost J, Tessadri R (1987) Trace element investigations in kidney stone patients. Eur Urol 13:264–270PubMed

Meyer J, Angino EE (1977) The role of trace metals in calcium urolithiasis. Invest Urol 14:347–350PubMed

10.

Munoz JA, Valiente M (2005) Effects of trace metals on the inhibition of calcium oxalate crystallization. Urol Res 33:267–272. doi:10.1007/s00240-005-0468-4 CrossRefPubMed

11.

Lang IA, Scarlett A, Guralnik JM, Depledge MH, Melzer D, Galloway TS (2009) Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999–2004. J Toxicol Environ Health A 72:402–409. doi:10.1080/15287390802647336 CrossRefPubMed

12.

Mucha L, Stephenson J, Morandi N, Dirani R (2006) Meta-analysis of disease risk associated with smoking, by gender and intensity of smoking. Gend Med 3:279–291CrossRefPubMed

13.

Liu CC, Huang SP, Wu WJ, Chou YH, Hank Juo SH, Tsai LY, Huang CH, Wu MT (2009) The impact of cigarette smoking, alcohol drinking and betel quid chewing on the risk of calcium urolithiasis. Ann Epidemiol 19:539–545. doi:10.1016/j.annepidem.2009.02.006 CrossRefPubMed

14.

Farrington CJ, Liddy ML, Chalmers AH (1980) A simplified sensitive method for the analysis of renal calculi. Am J Clin Pathol 73:96–99PubMed

15.

Larsson L, Sörbo B, Tiselius HG, Ohman S (1984) A method for quantitative wet chemical analysis of urinary calculi. Clin Chim Acta 140:9–20CrossRefPubMed

16.

Abraham PA, Smith CL (1987) Evaluation of factors involved in calcium stone formation. Mineral Electrolyte Metab 13:201–208

17.

Durak I, Kilic Z, Perk H, Sahin A, Yurtaslani Z, Yasar A, Küpeli S, Akpoyraz M (1990) Iron, copper, cadmium, zinc and magnesium contents of urinary tract stones and hair from men with stone disease. Eur Urol 17:243–247PubMed

18.

Perk H, Serel TA, Kosar A, Deniz N, Sayin A (2002) Analysis of the trace element contents of inner nucleus and outer crust parts of urinary calculi. Urol Int 68:286–290CrossRefPubMed

19.

Scott R, East BW, Janczyszyn J, Boddy K, Yates AJ (1980) Concentration of some minor and trace elements in urinary tract stones: a preliminary study. Urol Res 8:167–169CrossRefPubMed

20.

Hamano S, Nakatsu H, Suzuki N, Tomioka S, Tanaka M, Murakami S (2005) Kidney stone disease and risk factors for coronary heart disease. Int J Urol 12:859–863. doi:10.1111/j.1442-2042.2005.01160.x CrossRefPubMed

21.

Durak I, Sahin A, Perk H (1990) Smoking, hair cadmium and urinary tract stones. Eur Urol 17:267–268PubMed

22.

Mortada WI, Sobh MA, El-Defrawy MM (2004) The exposure to cadmium, lead and mercury from smoking and its impact on renal integrity. Med Sci Monit 10:112–116

23.

Gałażyn-Sidorczuk M, Brzóska MM, Moniuszko-Jakoniuk J (2008) Estimation of Polish cigarettes contamination with cadmium and lead, and exposure to these metals via smoking. Environ Monit Assess 137:481–493. doi:10.1007/s10661-007-9783-2 CrossRefPubMed

24.

Trevisan A, Gardin C (2005) Nephrolithiasis in a worker with cadmium exposure in the past. Int Arch Occup Environ Health 78:670–672. doi:10.1007/s00420-005-0009-z CrossRefPubMed

25.

Scott R, Cunningham C, McLelland A, Fell GS, Fitzgerald-Finch OP, McKellar N (1982) The importance of cadmium as a factor in calcified upper urinary tract stone disease-a prospective 7-year study. Br J Urol 54:584–589CrossRefPubMed

26.

Bird ED, Thomas WC (1963) Effect of various metals on mineralization in vitro. Proc Soc Exp Biol Med 112:640–643PubMed

27.

Rangnekar GV, Gaur MS (1993) Serum and urinary zinc levels in urolithiasis. Br J Urol 71:527–529CrossRefPubMed

28.

Hirvonen T, Pietinen P, Virtanen M, Albanes D, Virtamo J (1999) Nutrient intake and use of beverages and the risk of kidney stones among male smokers. Am J Epidemiol 150:187–194PubMed

Title: Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?
Authors: Marcin Słojewski
Bogusław Czerny
Krzysztof Safranow
Marek Droździk
Andrzej Pawlik
Katarzyna Jakubowska
Maria Olszewska
Adam Gołąb
Elżbieta Byra
Dariusz Chlubek
Andrzej Sikorski
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Urolithiasis / Issue 6/2009
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI: https://doi.org/10.1007/s00240-009-0221-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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