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European Journal of Plastic Surgery

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24-07-2023 | Biomarkers | Original Paper

Prognostic serum biomarker for survival outcome in burn patients

Authors: Samah M. Elbastawesy, Mohamed M. Khedr, Mohamed A. Shama, Tamer Zidan, Asmaa A. Ghalwash, Fatma Gaber

Published in: European Journal of Plastic Surgery | Issue 6/2023

Abstract

Background

To predict the burn survival outcome, diverse studies were carried out. Some trials reported prognostic scoring systems. However, other studies evaluated the role of different biochemical markers for the same purpose. Inflammation and tissue remodeling may be influenced by serum netrin-1. Our goal was to evaluate the prognostic value of serum netrin-1 level in the survival of burn patients.

Methods

Fifty-two burn patients participated in this prospective trial. Forty-two survived (group 1) and ten patients died (group 2). All patients’ data were gathered including physical examination, laboratory (routine investigations and serum netrin-1 level), and survival outcome. All patients had their serum netrin-1 levels checked once upon admission.

Results

The median level of serum netrin-1 in the non-survivor group was considerably greater than in the survivor group. Serum netrin-1 can be adopted to distinguish between the survivor group and non-survivor one at a cut-off level of > 94 (pg/mL), with 100% sensitivity and 54.76% specificity. Moreover, a significant positive strong correlation was detected between serum netrin-1 level and total burn surface area and prothrombin time.

Conclusions

Serum netrin-1 level could be used as a prognostic serum biomarker for survival outcomes in burn patients.

Level of evidence

Level IV, Risk/Prognostic study

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Title: Prognostic serum biomarker for survival outcome in burn patients
Authors: Samah M. Elbastawesy
Mohamed M. Khedr
Mohamed A. Shama
Tamer Zidan
Asmaa A. Ghalwash
Fatma Gaber
Publication date: 24-07-2023
Publisher: Springer Berlin Heidelberg
Keyword: Biomarkers
Published in: European Journal of Plastic Surgery / Issue 6/2023
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI: https://doi.org/10.1007/s00238-023-02087-9

2024 ASCO Annual Meeting

Springer Medicine

Prognostic serum biomarker for survival outcome in burn patients

Abstract

Background

Methods

Results

Conclusions

Level of evidence

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Level of evidence

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