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Neuroradiology

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01-03-2010 | Diagnostic Neuroradiology

An enhanced voxel-based morphometry method to investigate structural changes: application to Alzheimer’s disease

Authors: Xingfeng Li, Arnaud Messé, Guillaume Marrelec, Mélanie Pélégrini-Issac, Habib Benali

Published in: Neuroradiology | Issue 3/2010

Abstract

Introduction

When characterizing regional cerebral gray matter differences in structural magnetic resonance images (sMRI) by voxel-based morphometry (VBM), one faces a known drawback of VBM, namely that histogram unequalization in the intensity images introduces false-positive results.

Methods

To overcome this limitation, we propose to improve VBM by a new approach (called eVBM for enhanced VBM) that takes the histogram distribution of the sMRI into account by adding a histogram equalization step within the VBM procedure. Combining this technique with two most widely used VBM software packages (FSL and SPM), we studied GM variability in a group of 62 patients with Alzheimer’s disease compared to 73 age-matched elderly controls.

Results

The results show that eVBM can reduce the number of false-positive differences in gray matter concentration.

Conclusion

Because it takes advantage of the properties of VBM while improving sMRI histogram distribution at the same time, the proposed method is a powerful approach for analyzing gray matter differences in sMRI and may be of value in the investigation of sMRI gray and white matter abnormalities in a variety of brain diseases.

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Title: An enhanced voxel-based morphometry method to investigate structural changes: application to Alzheimer’s disease
Authors: Xingfeng Li
Arnaud Messé
Guillaume Marrelec
Mélanie Pélégrini-Issac
Habib Benali
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 3/2010
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-009-0600-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An enhanced voxel-based morphometry method to investigate structural changes: application to Alzheimer’s disease

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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