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01-04-2019 | Osteoarthrosis | Original Research

OPG is Required for the Postnatal Maintenance of Condylar Cartilage

Authors: Danying Chen, Yi Liu, Zongxiang Liu, Penglai Wang

Published in: Calcified Tissue International | Issue 4/2019

Abstract

Osteoprotegerin (OPG) is one of the protective factors of bony tissue. However, the function of OPG in cartilage tissues remains elusive. The aim of this study is to explore the function of OPG in the postnatal maintenance and the occurring of osteoarthritis (OA) of temporomandibular joint (TMJ) in the rodent models. We found that OPG expressed in the hypertrophic layer of the condylar cartilage and upregulated in the hyperocclusion-induced-TMJ-trauma rat. In the absence of OPG, the cartilage degradation occurred prior to that in WT mice, and the 3-month-old OPG-Knockout (OPG-KO) condyle showed decreased chondrocyte proliferation and increased chondrocyte apoptosis, whereas the number of chondroclasts was comparable to WT condyle. The isolated chondrocytes from the OPG-KO mice also showed impaired survival and promoted chondrogenic differentiation. Furthermore, the hyperocclusion model deteriorated TMJ degradation in the OPG-KO mice. OPG plays a protective role in the condylar chondrocytes’ survival, and it is required for the postnatal maintenance of TMJ.

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Title: OPG is Required for the Postnatal Maintenance of Condylar Cartilage
Authors: Danying Chen
Yi Liu
Zongxiang Liu
Penglai Wang
Publication date: 01-04-2019
Publisher: Springer US
Keywords: Osteoarthrosis
Osteoarthrosis
Published in: Calcified Tissue International / Issue 4/2019
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-018-00510-z

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