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Calcified Tissue International
Published in: Calcified Tissue International 2/2011

01-08-2011 | Original Research

Experimental Stimulation of Bone Healing with Teriparatide: Histomorphometric and Microhardness Analysis in a Mouse Model of Closed Fracture

Authors: Barbara Mognetti, Silvia Marino, Alessandro Barberis, Anne-Sophie Bravo Martin, Yohann Bala, Francesco Di Carlo, Georges Boivin, Michele Portigliatti Barbos

Published in: Calcified Tissue International | Issue 2/2011

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Abstract

Fracture consolidation is a crucial goal to achieve as early as possible, but pharmacological stimulation has been neglected so far. Teriparatide has been considered for this purpose for its anabolic properties. We set up a murine model of closed tibial fracture on which different doses of teriparatide were tested. Closed fracture treatment avoids any bias introduced by surgical manipulations. Teriparatide’s effect on callus formation was monitored during the first 4 weeks from fracture. Callus evolution was determined by histomorphometric and microhardness assessment. Daily administration of 40 μg/kg of teriparatide accelerated callus mineralization from day 9 onward without significant increase of sizes, and at day 15 the microhardness properties of treated callus were similar to those of bone tissue. Teriparatide considerably improved callus consolidation in the very early phases of bone healing.
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Metadata
Title
Experimental Stimulation of Bone Healing with Teriparatide: Histomorphometric and Microhardness Analysis in a Mouse Model of Closed Fracture
Authors
Barbara Mognetti
Silvia Marino
Alessandro Barberis
Anne-Sophie Bravo Martin
Yohann Bala
Francesco Di Carlo
Georges Boivin
Michele Portigliatti Barbos
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Calcified Tissue International / Issue 2/2011
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-011-9503-3

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