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01-01-2015 | Original Article

Calcifediol versus vitamin D₃ effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

Authors: O. Meyer, B. Dawson-Hughes, E. Sidelnikov, A. Egli, D. Grob, H. B. Staehelin, G. Theiler, R. W. Kressig, H. P. Simmen, R. Theiler, H. A. Bischoff-Ferrari

Published in: Osteoporosis International | Issue 1/2015

Abstract

Summary

In this double-blind RCT, 4-month treatment with calcifediol compared with vitamin D₃ improved gait speed by 18 % among young postmenopausal women. Consistently, change in 25(OH)D blood levels over time were significantly correlated with improvement in gait speed in these women. No effect could be demonstrated for trunk sway.

Introduction

The aim of this study is to test the effect of calcifediol compared with vitamin D₃ on gait speed and trunk sway.

Methods

Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ng/ml (SD = ±3.9) and a mean age of 61.5 years (SD = ±7.2) were randomized to either 20 μg of calcifediol or 20 μg (800 IU) of vitamin D₃ per day in a double-blind manner. At baseline and at 4 months of follow-up, the same physiotherapist blinded to treatment allocation tested 8-m gait speed and a body sway test battery (Sway star pitch and roll angle plus velocity while walking 8 m, and standing on both legs on a hard and soft surface). All analyses adjusted for baseline measurement, age, and body mass index.

Results

Mean 25(OH)D levels increased to 69.3 ng/ml (SD = ±9.5) in the calcifediol group and to 30.5 ng/ml (SD = ±5.0) in the vitamin D₃ group (p < 0.0001). Women receiving calcifediol compared with vitamin D₃ had an 18 % greater improvement in gait speed at 4-month follow-up (p = 0.046) adjusting for baseline gait speed, age, and body mass index. Also, change in gait speed was significantly correlated with change in serum 25(OH)D concentrations (r = 0.5; p = 0.04). Across three tests of trunk sway, there were no consistent differences between groups and no significant correlation between change in 25(OH)D serum concentrations and change in trunk sway.

Conclusions

Calcifediol improved gait speed in early postmenopausal women compared with vitamin D₃ and change in 25(OH)D level was moderately correlated with improvement in gait speed. A benefit on trunk sway could not be demonstrated.

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Cummings, SR, Studenski S and Ferrucci L (2014) A diagnosis of dismobility-giving mobility clinical visibility: a mobility working group recommendation. JAMA

Vermeulen J et al (2011) Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr 11:33PubMedCentralPubMedCrossRef

Cawthon PM et al (2009) Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults? J Am Geriatr Soc 57(8):1411–9PubMedCentralPubMedCrossRef

Studenski S et al (2011) Gait speed and survival in older adults. JAMA 305(1):50–8PubMedCentralPubMedCrossRef

Wicherts IS et al (2007) Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 6:6

Bischoff-Ferrari HA et al (2004) Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > =60 y. Am J Clin Nutr 80(3):752–8PubMed

Toffanello ED et al (2012) Vitamin D and physical performance in elderly subjects: the Pro.V.A study. PLoS One 7(4):e34950PubMedCentralPubMedCrossRef

Annweiler C et al (2010) Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res 25(8):1858–66PubMedCrossRef

Houston DK et al (2007) Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 62(4):440–6PubMedCentralPubMedCrossRef

10.

Dam TT, von Muhlen D, Barrett-Connor EL (2009) Sex-specific association of serum vitamin D levels with physical function in older adults. Osteoporos Int 20(5):751–60PubMedCentralPubMedCrossRef

11.

Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59(12):2291–300PubMedCrossRef

12.

Latham NK et al (2003) A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the frailty interventions trial in elderly subjects (FITNESS). J Am Geriatr Soc 51(3):291–9PubMedCrossRef

13.

Gallagher JC (2004) The effects of calcitriol on falls and fractures and physical performance tests. J Steroid Biochem Mol Biol 89–90(1–5):497–501PubMedCrossRef

14.

Bunout D et al (2006) Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 41(8):746–52PubMedCrossRef

15.

Dhesi JK et al (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33(6):589–95PubMedCrossRef

16.

Pfeifer M et al (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20(2):315–22PubMedCrossRef

17.

Bischoff-Ferrari HA et al (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19(2):265–9PubMedCrossRef

18.

Ceglia L et al (2010) Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 41(2–3):137–42PubMedCentralPubMedCrossRef

19.

Wang Y, Becklund BR, DeLuca HF (2010) Identification of a highly specific and versatile vitamin D receptor antibody. Arch Biochem Biophys 494(2):166–77PubMedCrossRef

20.

Sorensen OH et al (1979) Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci (Colch) 56(2):157–61

21.

Ceglia L, et al (2013) A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab

22.

Endo I et al (2003) Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144(12):5138–44PubMedCrossRef

23.

Bouillon R, Bischoff-Ferrari H, Willett W (2008) Vitamin D and health: perspectives from mice and man. J Bone Miner Res 23(7):974–9PubMedCrossRef

24.

Al-Shoha A et al (2009) Osteomalacia with bone marrow fibrosis due to severe vitamin D deficiency after a gastrointestinal bypass operation for severe obesity. Endocr Pract 15(6):528–33PubMedCrossRef

25.

Schott GD, Wills MR (1976) Muscle weakness in osteomalacia. Lancet 1(7960):626–9PubMedCrossRef

26.

Jetter A, et al (2013) Pharmacokinetics of oral vitamin D3 and calcifediol. Bone

27.

Cashman KD et al (2012) Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr 95(6):1350–6PubMedCrossRef

28.

Bischoff-Ferrari HA et al (2012) Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res 27(1):160–9PubMedCrossRef

29.

Jetter A et al (2014) Pharmacokinetics of oral vitamin D(3) and calcifediol. Bone 59:14–9PubMedCrossRef

30.

de Hoon EW et al (2003) Quantitative assessment of the stops walking while talking test in the elderly. Arch Phys Med Rehabil 84(6):838–42PubMedCrossRef

31.

Allum JH, Carpenter MG (2005) A speedy solution for balance and gait analysis: angular velocity measured at the centre of body mass. Curr Opin Neurol 18(1):15–21PubMedCrossRef

32.

Schmidt-Gayk H et al (2004) Performance evaluation of automated assays for beta-CrossLaps, N-MID-Osteocalcin and intact parathyroid hormone (BIOROSE Multicenter Study). Clin Chem Lab Med 42(1):90–5PubMedCrossRef

33.

Houston DK et al (2012) 25-hydroxyvitamin D status and change in physical performance and strength in older adults: the health, aging, and body composition study. Am J Epidemiol 176(11):1025–34PubMedCentralPubMedCrossRef

34.

Bischoff-Ferrari HA et al (2006) Is fall prevention by vitamin D mediated by a change in postural or dynamic balance? Osteoporos Int 17(5):656–63PubMedCrossRef

35.

Sambrook PN et al (2004) Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 89(4):1572–6PubMedCrossRef

36.

Morris GS et al (2012) Greater than age-predicted functional deficits in older patients with primary hyperparathyroidism. Endocr Pract 18(4):450–5PubMedCrossRef

Title: Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial
Authors: O. Meyer
B. Dawson-Hughes
E. Sidelnikov
A. Egli
D. Grob
H. B. Staehelin
G. Theiler
R. W. Kressig
H. P. Simmen
R. Theiler
H. A. Bischoff-Ferrari
Publication date: 01-01-2015
Publisher: Springer London
Published in: Osteoporosis International / Issue 1/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2949-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Calcifediol versus vitamin D₃ effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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