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Published in: Osteoporosis International 1/2015

01-01-2015 | Original Article

Magnitude of fragility fracture risk in the very old—are we meeting their needs? The Newcastle 85+ Study

Authors: R. Duncan, R. M. Francis, C. Jagger, A. Kingston, E. McCloskey, J. Collerton, L. Robinson, T. B. L. Kirkwood, F. Birrell

Published in: Osteoporosis International | Issue 1/2015

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Abstract

Summary

Fractures due to osteoporosis are common in older people. This study assessed the management of osteoporosis in a group of 85-year-olds and found both assessment and current treatment to be suboptimal.

Introduction

Fragility fractures are a major cause of excess mortality, substantial morbidity, and health and social service expenditure in older people. However, much less is known about fracture risk and its management in the very old, despite this being the fastest growing age group of our population.

Methods

Cross-sectional analysis of people who reached the age of 85 during the year of 2006 was carried out. Data were gathered by general practice record review (GPRR) and a multidimensional health assessment (MDHA).

Results

Seven hundred thirty-nine individuals were recruited. Mean age was 85.55 years (SD 0.44), and 60.2 % were female; 33.7 % (n = 249) had experienced one or more fragility fractures (F 45.2 % vs M 16.3 % p < 0.001); in total, 332 fractures occurred in these 249 individuals. A formal documented diagnosis of osteoporosis occurred in 12.4 %, and 38 % of individuals had experienced a fall in the last 12 months. When the fracture risk assessment tool (FRAX) and National Osteoporosis Guideline Group (NOGG) guidelines were applied, osteoporosis treatment would be recommended in 35.0 %, with a further 26.1 % identified as needing bone mineral density (BMD) measurement and 38.9 % not requiring treatment or BMD assessment. Women were more likely than men to need treatment (47.4 vs 16.3 %, p < 0.001, odds ratio (OR) 4.62 (3.22–5.63)) and measurement of BMD (40.0 vs 5.1 %, p < 0.001, OR 12.4 (7.13–21.6)). Of the 259 individuals identified as requiring treatment, only 74 (28.6 %) were on adequate osteoporosis treatment.

Conclusion

The prevalence of high fracture risk in the very old is much higher than the documented diagnosis of osteoporosis or the use of adequate treatments.
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Literature
1.
go back to reference Consensus Development Conference (1991) Prophylaxis and treatment of osteoporosis. Am J Med 90:107–110CrossRef Consensus Development Conference (1991) Prophylaxis and treatment of osteoporosis. Am J Med 90:107–110CrossRef
2.
go back to reference Johansen A, Evans RJ, Stone MD, Richmond PW, Lo SV, Woodhouse KW (1997) Fracture incidence in England and Wales: a study based on the population of Cardiff. Injury 28:655–660PubMedCrossRef Johansen A, Evans RJ, Stone MD, Richmond PW, Lo SV, Woodhouse KW (1997) Fracture incidence in England and Wales: a study based on the population of Cardiff. Injury 28:655–660PubMedCrossRef
3.
go back to reference van Staa TP, Dennison EM, Leufkens HGM, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522PubMedCrossRef van Staa TP, Dennison EM, Leufkens HGM, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522PubMedCrossRef
4.
go back to reference Francis RM (2010) Metabolic bone disease. In: Tallis RC, Fillit HM, Woodhouse K (eds) Brocklehurst’s textbook of geriatric medicine and gerontology, 7th edn. W.B.Saunders, pp 553–565 Francis RM (2010) Metabolic bone disease. In: Tallis RC, Fillit HM, Woodhouse K (eds) Brocklehurst’s textbook of geriatric medicine and gerontology, 7th edn. W.B.Saunders, pp 553–565
6.
go back to reference Kanis JA, on behalf of the World Health Organization Scientific Group (2008) Assessment of osteoporosis at the primary health-care level. Technical Report. WHO Collaborating Centre, University of Sheffield, UK. http://www.shef.ac.uk/FRAX/tool.jsp. Accessed 14 Jan 2014 Kanis JA, on behalf of the World Health Organization Scientific Group (2008) Assessment of osteoporosis at the primary health-care level. Technical Report. WHO Collaborating Centre, University of Sheffield, UK. http://​www.​shef.​ac.​uk/​FRAX/​tool.​jsp. Accessed 14 Jan 2014
9.
go back to reference Boffin N, Moreels S, Vanthomme K, Van Casteren V (2014) Falls among older general practice patients: a 3 = year nationwide surveillance study. Fam Pract 31(3):281–289PubMedCrossRef Boffin N, Moreels S, Vanthomme K, Van Casteren V (2014) Falls among older general practice patients: a 3 = year nationwide surveillance study. Fam Pract 31(3):281–289PubMedCrossRef
10.
go back to reference Collerton J, Barrass K, Bond J, Eccles M, Jagger C, James O, Martin-Ruiz C, Robinson L, von Zglinicki T, Kirkwood T (2007) The Newcastle 85+ study: biological, clinical and psychological factors associated with healthy ageing: study protocol. BMC Geriatr 7:14PubMedCentralPubMedCrossRef Collerton J, Barrass K, Bond J, Eccles M, Jagger C, James O, Martin-Ruiz C, Robinson L, von Zglinicki T, Kirkwood T (2007) The Newcastle 85+ study: biological, clinical and psychological factors associated with healthy ageing: study protocol. BMC Geriatr 7:14PubMedCentralPubMedCrossRef
11.
go back to reference Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles M, Robinson L, Martin-Ruiz C, von Zglinicki T, James O, Kirkwood TBL (2009) Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ 399:b4904CrossRef Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles M, Robinson L, Martin-Ruiz C, von Zglinicki T, James O, Kirkwood TBL (2009) Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ 399:b4904CrossRef
13.
go back to reference Simpson CF, Boyd CM, Carlson MC, Griswold ME, Guralnik JM, Fried LP (2004) Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement. J Am Geriatr Soc 52:123–127PubMedCrossRef Simpson CF, Boyd CM, Carlson MC, Griswold ME, Guralnik JM, Fried LP (2004) Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement. J Am Geriatr Soc 52:123–127PubMedCrossRef
14.
go back to reference Kriegsman D, Penninx BW, van Eijk JT, Boeke AJP, Deeg DJH (1996) Self-reports and General Practitioner Information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients’ self-reports and on determinants of inaccuracy. J Clin Epidemiol 49(12):1407–1417PubMedCrossRef Kriegsman D, Penninx BW, van Eijk JT, Boeke AJP, Deeg DJH (1996) Self-reports and General Practitioner Information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients’ self-reports and on determinants of inaccuracy. J Clin Epidemiol 49(12):1407–1417PubMedCrossRef
16.
go back to reference Royal College of Physicians (1999) Osteoporosis: clinical guidelines for prevention and treatment. Royal College of Physicians, London Royal College of Physicians (1999) Osteoporosis: clinical guidelines for prevention and treatment. Royal College of Physicians, London
17.
go back to reference Johnell K, Fastbom J (2009) Undertreatment of osteoporosis in the oldest old? A nationwide study of over 700,000 older people. Arch Osteoporos 4:17–23PubMedCentralPubMedCrossRef Johnell K, Fastbom J (2009) Undertreatment of osteoporosis in the oldest old? A nationwide study of over 700,000 older people. Arch Osteoporos 4:17–23PubMedCentralPubMedCrossRef
18.
go back to reference Huot L, Couris CM, Tainturier V, Jaglal S, Colin C, Schott A-M (2008) Trends in HRT and anti-osteoporosis medication prescribing in a European population after the WHI study. Osteoporos Int 19:1047–1054PubMedCrossRef Huot L, Couris CM, Tainturier V, Jaglal S, Colin C, Schott A-M (2008) Trends in HRT and anti-osteoporosis medication prescribing in a European population after the WHI study. Osteoporos Int 19:1047–1054PubMedCrossRef
19.
go back to reference Vannasse A, Dagenais P, Niyonsenga T, Gregoire P, Courteau J, Hemiari A (2005) Bone mineral density measurement and osteoporosis treatment after a fragility fracture in older adults: regional variation and determinants of use in Quebec. BMC Musculoskelet Dis 6:33CrossRef Vannasse A, Dagenais P, Niyonsenga T, Gregoire P, Courteau J, Hemiari A (2005) Bone mineral density measurement and osteoporosis treatment after a fragility fracture in older adults: regional variation and determinants of use in Quebec. BMC Musculoskelet Dis 6:33CrossRef
20.
go back to reference Lekkerkerker F, Kanis JA, Alsayed N (2007) Adherence to treatment of osteoporosis: a need for study. Osteoporos Int 18:1311–1317PubMedCrossRef Lekkerkerker F, Kanis JA, Alsayed N (2007) Adherence to treatment of osteoporosis: a need for study. Osteoporos Int 18:1311–1317PubMedCrossRef
21.
go back to reference Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, Brookhart A (2005) Compliance with osteoporosis medications. Arch Intern Med 165:2414–2419PubMedCrossRef Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, Brookhart A (2005) Compliance with osteoporosis medications. Arch Intern Med 165:2414–2419PubMedCrossRef
22.
go back to reference Burge RT, Worley D, Johansen A, Bhattacharyya S, Bose U (2001) The cost of osteoporotic fractures in the UK: projections for 2000–2020. J Med Econ 4:51–62CrossRef Burge RT, Worley D, Johansen A, Bhattacharyya S, Bose U (2001) The cost of osteoporotic fractures in the UK: projections for 2000–2020. J Med Econ 4:51–62CrossRef
23.
go back to reference Miller AG, Bercik MJ, Ong A (2012) Nonagenarian hip fracture: treatment and complications. J Trauma Acute Care Surg 72:1411–1415PubMed Miller AG, Bercik MJ, Ong A (2012) Nonagenarian hip fracture: treatment and complications. J Trauma Acute Care Surg 72:1411–1415PubMed
25.
go back to reference McLellan AR, Gallacher SJ, Fraser M, McQuillian C (2003) The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int 14:1028–1034PubMedCrossRef McLellan AR, Gallacher SJ, Fraser M, McQuillian C (2003) The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int 14:1028–1034PubMedCrossRef
26.
go back to reference Eastell R, Reid DM, Compston J, Cooper C, Fogelman I, Francis RM, Hay SM, Hosking DJ, Purdie DW, Ralston SH, Reeve J, Russell RG, Stevenson JC (2001) Secondary prevention of osteoporosis: when should a non-vertebral fracture be a trigger for action? QJM 94:575–597PubMedCrossRef Eastell R, Reid DM, Compston J, Cooper C, Fogelman I, Francis RM, Hay SM, Hosking DJ, Purdie DW, Ralston SH, Reeve J, Russell RG, Stevenson JC (2001) Secondary prevention of osteoporosis: when should a non-vertebral fracture be a trigger for action? QJM 94:575–597PubMedCrossRef
Metadata
Title
Magnitude of fragility fracture risk in the very old—are we meeting their needs? The Newcastle 85+ Study
Authors
R. Duncan
R. M. Francis
C. Jagger
A. Kingston
E. McCloskey
J. Collerton
L. Robinson
T. B. L. Kirkwood
F. Birrell
Publication date
01-01-2015
Publisher
Springer London
Published in
Osteoporosis International / Issue 1/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-014-2837-8

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