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Osteoporosis International

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01-08-2009 | Review

Depression and low bone mineral density: a meta-analysis of epidemiologic studies

Authors: Q. Wu, J. H. Magnus, J. Liu, A. F. Bencaz, J. G. Hentz

Published in: Osteoporosis International | Issue 8/2009

Abstract

Summary

The association between depression and loss of bone mineral density (BMD) has been reported inconsistently. This meta-analysis, which pooled results from 14 qualifying individual studies, found that depression was associated with a significantly decreased BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression.

Introduction

The reported association between depression and loss of BMD has been controversial. This meta-analysis was conducted to determine whether depression and BMD are associated and to identify the variation in some subgroups.

Methods

English-language articles published before October 2008 were used as the data source. A total of six case-controlled and eight cross-sectional studies met prestated inclusion criteria (N = 10,523). Information on study design, participant characteristics, measurements of BMD and depression, and control for potential confounders was abstracted independently by two investigators using a standardized protocol.

Results

Overall, depression was associated with a significant decrease in mean BMD of spine (−0.053 g/cm² [95% confidence interval {CI} −0.087 to −0.018 g/cm²]) and hip (−0.052 g/cm² [95% CI −0.083 to −0.022 g/cm²]). A substantially greater BMD decrease was observed in depressed women (−0.076 g/cm² in spine; −0.059 g/cm² in hip) and in cases of clinical depression (−0.074 g/cm² in spine; −0.080 g/cm² in hip).

Conclusion

Depression is associated with low BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression. Depression should be considered as an important risk factor for osteoporosis.

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Title: Depression and low bone mineral density: a meta-analysis of epidemiologic studies
Authors: Q. Wu
J. H. Magnus
J. Liu
A. F. Bencaz
J. G. Hentz
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 8/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0918-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Depression and low bone mineral density: a meta-analysis of epidemiologic studies

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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