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Osteoporosis International

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Open Access 01-08-2009 | Original Article

Racial difference in the correlates of bone mineral content/density and age at peak among reproductive-aged women

Authors: A. B. Berenson, M. Rahman, G. Wilkinson

Published in: Osteoporosis International | Issue 8/2009

Abstract

Summary

Racial/ethnic differences were observed in age at peak bone density and their correlates, with whites peaking at least 5 years earlier at the femoral neck than black and Hispanic women. Race-specific standards generated in this study could be useful when interpreting bone densitometry data in young women.

Introduction

The influence of race/ethnicity on bone measurements has not been widely examined. This study identifies age and amount of bone accumulated at peak density and their correlates by race/ethnicity.

Methods

Bone mineral content (BMC) and bone mineral density (BMD) of the spine and femoral neck were measured by dual X-ray absorptiometry in 708 white, black, and Hispanic reproductive-aged women. Race-specific nonlinear models were used to describe the relationship between age and bone measurements, after adjusting for body weight and height. Log-transformed bone measurements were used to determine predictors based on multiple linear regression.

Results

Predictors, which were race and site specific, included age, age at menarche, body weight, height, months of depot medroxyprogesterone acetate use, weight-bearing exercise, and alcohol use. Women of all races gained BMC and BMD at the spine up to 30–33 years of age. BMC and BMD of the femoral neck peaked among white women earlier (≤16 years) than among blacks (BMC 22 years; BMD 21 years) and Hispanics (BMC 29 years; BMD 20 years).

Conclusion

Age at peak bone mass and its correlates differ by race/ethnicity. Race-specific standards generated in this study could be useful when interpreting bone densitometry data in young women.

National Institutes of Health (2007) Osteoporosis Overview. Osteoporosis and Related Bone Diseases National Resource Center. http://www.niams.nih.gov/Health_Info/Bone/Osteoporosis/default.asp. Accessed May 13, 2008

Sabatier JP, Guaydier-Souquieres G, Benmalek A et al (1999) Evolution of lumbar bone mineral content during adolescence and adulthood: A longitudinal study in 395 healthy females 10–24 years of age and 206 premenopausal women. Osteoporos Int 9:476–482PubMedCrossRef

van der Sluis I, de Ridder MA, Boot AM et al (2002) Reference data for bone density and body composition measured with dual energy X-ray absorptiometry in white children and young adults. Arch Dis Child 87:341–347PubMedCrossRef

Lloyd T, Chinchilli VM, Eggli DF et al (1998) Body composition development of adolescent white females: The Penn State Young Women’s Health Study. Arch Pediatr Adolesc Med 152:998–1002PubMed

Lin YC, Lyle RM, Weaver CM et al (2003) Peak spine and femoral neck bone mass in young women. Bone 32:546–553PubMedCrossRef

Henry YM, Fatayerji D, Eastell R (2004) Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density. Osteoporos Int 15:263–273PubMedCrossRef

Wren TA, Kim PS, Janicka A et al (2007) Timing of peak bone mass: discrepancies between CT and DXA. J Clin Endocrinol Metab 92:938–941PubMedCrossRef

Kalkwarf HJ, Zemel BS, Gilsanz V et al (2007) The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. J Clin Endocrinol Metab 92:2087–2099PubMedCrossRef

Cromer BA, Binkovitz L, Ziegler J et al (2004) Reference values for bone mineral density in 12- to 18-year-old girls categorized by weight, race, and age. Pediatr Radiol 34:787–792PubMedCrossRef

10.

Henry YM, Eastell R (2000) Ethnic and gender differences in bone mineral density and bone turnover in young adults: effect of bone size. Osteoporos Int 11:512–517PubMedCrossRef

11.

Bachrach LK, Hastie T, Wang MC et al (1999) Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab 84:4702–4712PubMedCrossRef

12.

Harel Z, Gold M, Cromer B et al (2007) Bone mineral density in postmenarchal adolescent girls in the United States: associated biopsychosocial variables and bone turnover markers. J Adolesc Health 40:44–53PubMedCrossRef

13.

Wang MC, Aguirre M, Bhudhikanok GS et al (1997) Bone mass and hip axis length in healthy Asian, black, Hispanic, and white American youths. J Bone Miner Res 12:1922–1935PubMedCrossRef

14.

Hertzler AA, Frary RB (1994) A dietary calcium rapid assessment method (RAM). Top Clin Nutr 9:76–85

15.

World Health Organization (1999) Smoking Questionnaire. MONICA Manual (1998–1999), Part III, Section 1. The WHO MONICA (Multinational Monitoring Trends in Cardiovascular Disease) Project

16.

National Cancer Institute (2000) Diet History Questionnaire (DHQ). National Institutes of Health

17.

Kolle E, Torstveit MK, Sundgot-Borgen J (2005) Bone mineral density in Norwegian premenopausal women. Osteoporos Int 16:914–920PubMedCrossRef

18.

Baim S, Wilson CR, Lewiecki EM et al (2005) Precision assessment and radiation safety for dual-energy X-ray absorptiometry: position paper of the International Society for Clinical Densitometry. J Clin Densitom 8:371–378PubMedCrossRef

19.

Ravaud P, Reny JL, Giraudeau B et al (1999) Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res 14:1449–1456PubMedCrossRef

20.

Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed

21.

Carter DR, Bouxsein ML, Marcus R (1992) New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7:137–145PubMed

22.

Katzman DK, Bachrach LK, Carter DR et al (1991) Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab 73:1332–1339PubMedCrossRef

23.

Teegarden D, Proulx WR, Martin BR et al (1995) Peak bone mass in young women. J Bone Miner Res 10:711–715PubMed

24.

Cleveland WS (1979) Robust locally weighted regression and smoothing scatterplots. J Amer Statist Assoc 74:829–836CrossRef

25.

Kanders B, Dempster DW, Lindsay R (1988) Interaction of calcium nutrition and physical activity on bone mass in young women. J Bone Miner Res 3:145–149PubMed

26.

Lloyd T, Beck TJ, Lin HM et al (2002) Modifiable determinants of bone status in young women. Bone 30:416–421PubMedCrossRef

27.

Stevenson JC, Lees B, Devenport M et al (1989) Determinants of bone density in normal women: risk factors for future osteoporosis? BMJ 298:924–928PubMedCrossRef

28.

Sowers M, Wallace RB, Lemke JH (1985) Correlates of forearm bone mass among women during maximal bone mineralization. Prev Med 14:585–596PubMedCrossRef

29.

Rosenthal DI, Mayo-Smith W, Hayes CW et al (1989) Age and bone mass in premenopausal women. J Bone Miner Res 4:533–538PubMedCrossRef

30.

Sowers M, Corton G, Shapiro B et al (1993) Changes in bone density with lactation. JAMA 269:3130–3135PubMedCrossRef

31.

Theintz G, Buchs B, Rizzoli R et al (1992) Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab 75:1060–1065PubMedCrossRef

32.

Sabatier JP, Guaydier-Souquières G, Laroche D et al (1996) Bone mineral acquisition during adolescence and early adulthood: a study in 574 healthy females 10–24 years of age. Osteoporos Int 6:141–148PubMedCrossRef

33.

Haddock L, Ortiz V, Vazquez MD et al (1996) The lumbar and femoral bone mineral densities in a normal female Puerto Rican population. P R Health Sci J 15:5–11PubMed

34.

Fang J, Freeman R, Jeganathan R et al (2004) Variations in hip fracture hospitalization rates among different race/ethnicity groups in New York City. Ethn Dis 14:280–284PubMed

35.

Looker AC, Orwoll ES, Johnston CC et al (1997) Prevalence of low femoral bone density in older US adults from NHANES III. J Bone Miner Res 12:1761–1768PubMedCrossRef

36.

Castro JP, Joseph LA, Shin JJ et al (2005) Differential effect of obesity on bone mineral density in White, Hispanic and African American women: a cross sectional study. Nutr Metab (Lond) 2:9CrossRef

37.

Matkovic V, Goel PK, Badenhop-Stevens NE, Landoll JD, Li B, Ilich JZ, Skugor M, Nagode LA, Mobley SL, Ha EJ, Hangartner TN, Clairmont A (2005) Calcium supplementation and bone mineral density in females from childhood to young adulthood: a randomized controlled trial. Am J Clin Nutr 91:175–188

38.

Merrilees MJ, Smart EJ, Gilchrist NL, Frampton C, Turner JG, Hooke E, March RL, Maguire P (2000) Effects of dairy food supplements on bone mineral density in teenage girls. Eur J Nutr 39:256–262PubMedCrossRef

39.

Rozen GS, Rennert G, Dodiuk-Gad RP, Rennert HS, Ish-Shalom N, Diab G, Raz B, Ish-Shalom S (2003) Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche. Am J Clin Nutr 78:993–998PubMed

40.

Dodiuk-Gad RP, Rozen GS, Rennert G, Rennert HS, Ish-Shalom S (2005) Sustained effect of short-term calcium supplementation on bone mass in adolescent girls with low calcium intake. Am J Clin Nutr 81:168–174PubMed

41.

Zhu K, Greenfield H, Zhang Q, Du X, Ma G, Foo LH, Cowell CT, Fraser DR (2008) Growth and bone mineral accretion during puberty in Chinese girls: a five year longitudinal study. J Bone Miner Res 23:167–172PubMedCrossRef

42.

Mein AL, Briffa NK, Dhaliwal SS, Price RI (2004) Lifestyle influences on 9-year changes in BMD in young women. J Bone Miner Res 19:1092–1098PubMedCrossRef

43.

Lloyd T, Petit MA, Lin HM, Beck TJ (2004) Lifestyle factors and the development of bone mass and bone strength in young women. J Pediatr 144:776–782PubMed

44.

Welten DC, Kemper HC, Post GB, van Staveren WA (1995) A meta-analysis of the effect of calcium intake on bone mass in young and middle aged females and males. J Nutr 125:2802–2813PubMed

45.

National Institutes of Health, Office of Dietary Supplements. Dietary Supplement Fact Sheet: Calcium. http://ods.od.nih.gov/factsheets/calcium.asp. Accessed 22 July 2008

Title: Racial difference in the correlates of bone mineral content/density and age at peak among reproductive-aged women
Authors: A. B. Berenson
M. Rahman
G. Wilkinson
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 8/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0817-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Racial difference in the correlates of bone mineral content/density and age at peak among reproductive-aged women

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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