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Osteoporosis International

Published in:

01-05-2009 | Original Article

Sequential change in quality of life for patients with incident clinical fractures: a prospective study

Authors: H. Hagino, T. Nakamura, S. Fujiwara, M. Oeki, T. Okano, R. Teshima

Published in: Osteoporosis International | Issue 5/2009

Abstract

Summary

Health-related quality of life in elderly women with sustained incident fractures was assessed prospectively for 1 year, using the EuroQol standard. Loss of QOL was more severe in patients after hip or vertebral fractures than those with wrist fracture. QOL was not completely restored in patients suffering from hip fracture.

Introduction

Osteoporosis-related fractures decrease mobility, social interaction, and emotional well-being. All of these characteristics determine health-related quality of life (HR-QOL). In this study, we assessed HR-QOL in elderly women following incident clinical fractures.

Methods

Thirty-seven patients with hip fractures (mean age 76.1 years), 35 with vertebral fractures (mean age 72.6 years), and 50 with wrist fractures (mean age 68.6 years) were enrolled. HR-QOL was prospectively measured using EuroQol (EQ-5D) before the fracture, 2 weeks, 3 months, 6 months, and 1 year after the fracture.

Results

During the observation period, reduction of EQ-5D values was greatest in the hip fracture group. In the wrist fracture group, EQ-5D values at 6 months after the fracture showed recovery; however, in the hip and vertebral fracture groups, recovery was significantly lower than before the fracture. One year after the fracture, EQ-5D values were not significantly different from prefracture values in the vertebral and wrist fracture groups, but remained significantly lower in the hip fracture group.

Conclusions

Loss of QOL was more severe in patients after hip or vertebral fractures than in patients with wrist fracture. HR-QOL was not completely restored in patients suffering from hip fracture.

Lofman O, Berglund K, Larsson L et al (2002) Changes in hip fracture epidemiology: redistribution between ages, genders and fracture types. Osteoporos Int 13:18–25PubMedCrossRef

Jaglal SB, Weller I, Mamdani M et al (2005) Population trends in BMD testing, treatment, and hip and wrist fracture rates: are the hip fracture projections wrong? J Bone Miner Res 20:898–905PubMedCrossRef

Melton LJ 3rd, Atkinson EJ, Madhok R (1996) Downturn in hip fracture incidence. Public Health Rep 111:146–150 discussion 151PubMed

Kannus P, Niemi S, Parkkari J et al (2006) Nationwide decline in incidence of hip fracture. J Bone Miner Res 21:1836–1838PubMedCrossRef

Rowe SM, Song EK, Kim JS et al (2005) Rising incidence of hip fracture in Gwangju City and Chonnam Province, Korea. J Korean Med Sci 20:655–658PubMedCrossRef

Hagino H, Katagiri H, Okano T et al (2005) Increasing incidence of hip fracture in Tottori Prefecture, Japan: trend from 1986 to 2001. Osteoporos Int 16:1963–1968PubMedCrossRef

Hagino H, Yamamoto K, Ohshiro H et al (1999) Changing incidence of hip, distal radius, and proximal humerus fractures in Tottori Prefecture, Japan. Bone 24:265–270PubMedCrossRef

Boonen S, Autier P, Barette M et al (2004) Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study. Osteoporos Int 15:87–94PubMedCrossRef

Brenneman SK, Barrett-Connor E, Sajjan S et al (2006) Impact of recent fracture on health-related quality of life in postmenopausal women. J Bone Miner Res 21:809–816PubMedCrossRef

10.

Tidermark J, Zethraeus N, Svensson O et al (2002) Femoral neck fractures in the elderly: functional outcome and quality of life according to EuroQol. Qual Life Res 11:473–481PubMedCrossRef

11.

Marcus R, Wong M, Heath H 3rd et al (2002) Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint. Endocr Rev 23:16–37PubMedCrossRef

12.

Brazier JE, Green C, Kanis JA (2002) A systematic review of health state utility values for osteoporosis-related conditions. Osteoporos Int 13:768–776PubMedCrossRef

13.

Dolan P, Gudex C, Kind P et al (1996) The time trade-off method: results from a general population study. Health Econ 5:141–154PubMedCrossRef

14.

Ikeda S, Ikegami N (2001) Preference-based measure(EQ-5D) In: Ikegami N, Fukuhara S, Shimozuma K, Ikeda S (eds) QOL evaluation handbook for clinical practice(in Japanese). Igakushoin, Tokyo, pp 14–18

15.

Ikeda S, Ikegami N (1999) Health status in Japanese population: results from Japanese EuroQol study. Iryou to Shakai 9:83–92

16.

Nawata S, Yamad Y, Ikeda S et al (2000) EuroQol study of the elderly general population: Relationship with IADL and other attributes. Iryou to Shakai (in Japanese) 10:75–86

17.

Hallberg I, Rosenqvist AM, Kartous L et al (2004) Health-related quality of life after osteoporotic fractures. Osteoporos Int 15:834–841PubMedCrossRef

18.

Lips P, van Schoor NM (2005) Quality of life in patients with osteoporosis. Osteoporos Int 16:447–455PubMedCrossRef

19.

Oleksik AM, Ewing S, Shen W et al (2005) Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporos Int 16:861–870PubMedCrossRef

20.

Dhillon V, Hurst N, Hannan J et al (2005) Association of low general health status, measured prospectively by Euroqol EQ5D, with osteoporosis, independent of a history of prior fracture. Osteoporos Int 16:483–489PubMedCrossRef

21.

Sakamoto K, Nakamura T, Hagino H et al (2006) Report on the Japanese Orthopaedic Association’s 3-year project observing hip fractures at fixed-point hospitals. J Orthop Sci 11:127–134PubMedCrossRef

22.

Cranney AB, Coyle D, Hopman WM et al (2005) Prospective evaluation of preferences and quality of life in women with hip fractures. J Rheumatol 32:2393–2399PubMed

23.

Hall SE, Williams JA, Senior JA et al (2000) Hip fracture outcomes: quality of life and functional status in older adults living in the community. Aust N Z J Med 30:327–332PubMed

24.

Fierens J, Broos PL (2006) Quality of life after hip fracture surgery in the elderly. Acta Chir Belg 106:393–396PubMed

25.

Randell AG, Nguyen TV, Bhalerao N et al (2000) Deterioration in quality of life following hip fracture: a prospective study. Osteoporos Int 11:460–466PubMedCrossRef

26.

Oleksik A, Lips P, Dawson A et al (2000) Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures. J Bone Miner Res 15:1384–1392PubMedCrossRef

27.

Cockerill W, Lunt M, Silman AJ et al (2004) Health-related quality of life and radiographic vertebral fracture. Osteoporos Int 15:113–119PubMedCrossRef

28.

Dolan P, Torgerson D, Kakarlapudi TK (1999) Health-related quality of life of Colles’ fracture patients. Osteoporos Int 9:196–199PubMedCrossRef

29.

Lips P, Cooper C, Agnusdei D et al (1999) Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int 10:150–160PubMedCrossRef

30.

NOF (1998) Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis. Introduction. Osteoporos Int 8(Suppl 4):S7–S80

Title: Sequential change in quality of life for patients with incident clinical fractures: a prospective study
Authors: H. Hagino
T. Nakamura
S. Fujiwara
M. Oeki
T. Okano
R. Teshima
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 5/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0761-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sequential change in quality of life for patients with incident clinical fractures: a prospective study

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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