Published in:
01-05-2009 | Original Article
RETRACTED ARTICLE: Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study
Published in: Osteoporosis International | Issue 5/2009
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Summary
Nitrates may have beneficial effects on bone. To determine if nitrates were
associated with increased bone mineral density (BMD), we conducted a secondary
analysis using data from subjects in a prospective study. Subjects reporting
nitrate use had increased BMD compared with non-users, confirming that nitrates
have positive BMD effects in women and men.
Introduction
Prior studies suggest positive associations between nitrates and bone.
Methods
We used linear regression models, stratified by gender and adjusted for age,
weight, and baseline differences, to determine the association between daily
nitrate use and BMD among subjects participating in the Canadian Multicentre
Osteoporosis Study. All results are reported as annualised percent change in BMD
at the hip and spine among nitrate users compared to non-users.
Results
We included 1,419 men (71 reported daily nitrate use) and 2,587 women (97
reported daily nitrate use). Male non-users had decreased hip BMD (−1.3%; 95%
confidence interval [95%CI] = −1.6 to −1.1) and increased spine BMD (2.8%;
95%CI = 2.5 to 3.1). Male nitrate users had increased hip BMD (1.4%; 95%CI = 0.1
to 2.8) and spine BMD (4.5%; 95%CI = 3.2 to 5.7). Among women, non-users had
decreased hip BMD (−1.9; 95%CI = −2.1 to −1.7) and increased spine BMD (2.1%;
95%CI = 1.9 to 2.4) whilst users had an increase in hip BMD (2.0%; 95%CI = 1.2 to
2.8) and spine BMD (4.1%; 95%CI = 3.4 to 4.9).
Conclusion
Nitrate use is associated with increased BMD at the hip and spine in men and
women.