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International Urogynecology Journal

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Open Access 01-10-2012 | Review Article

A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Authors: Sabrina L. Lince, Leon C. van Kempen, Mark E. Vierhout, Kirsten B. Kluivers

Published in: International Urogynecology Journal | Issue 10/2012

Abstract

Introduction and hypothesis

There is growing evidence that pelvic organ prolapse (POP) is at least partly caused by underlying hereditary risk factors. The aim of our study was to provide a systematic literature review and meta-analysis of clinical studies on family history of POP as a risk factor for POP in individual women.

Methods

The databases PubMed and Embase were searched. Clinical studies reporting on family history of POP in relation to POP in individual women were included.

Results

Sixteen studies were included, of which eight enabled us to calculate a pooled odds ratio (OR). The pooled OR of POP in case of a positive family history of POP was 2.58 (95 % confidence interval 2.12–3.15).

Conclusions

Women with POP are substantially more likely to have family members with the same condition compared to women without POP. This strengthens the hypothesis that genetic predisposition plays an important role in the development of POP.

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Title: A systematic review of clinical studies on hereditary factors in pelvic organ prolapse
Authors: Sabrina L. Lince
Leon C. van Kempen
Mark E. Vierhout
Kirsten B. Kluivers
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 10/2012
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-012-1704-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A systematic review of clinical studies on hereditary factors in pelvic organ prolapse

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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