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International Urogynecology Journal
Published in: International Urogynecology Journal 8/2008

01-08-2008 | Original Article

Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk

Authors: Huey-Yi Chen, Ya-Wen Chung, Wei-Yong Lin, Wei-Chi Chen, Fuu-Jen Tsai, Chang-Hai Tsai

Published in: International Urogynecology Journal | Issue 8/2008

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Abstract

Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor α (ERα) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ERα (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ERα genotype may be associated with POP risk.
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Metadata
Title
Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk
Authors
Huey-Yi Chen
Ya-Wen Chung
Wei-Yong Lin
Wei-Chi Chen
Fuu-Jen Tsai
Chang-Hai Tsai
Publication date
01-08-2008
Publisher
Springer-Verlag
Published in
International Urogynecology Journal / Issue 8/2008
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-008-0603-1

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