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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-06-2014 | Experimental Study

Quantitative MRI in the evaluation of articular cartilage health: reproducibility and variability with a focus on T2 mapping

Authors: Rachel K. Surowiec, Erin P. Lucas, Charles P. Ho

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2014

Abstract

Purpose

Early diagnosis of cartilage degeneration and longitudinal tracking of cartilage health including repair following surgical intervention would benefit from the ability to detect and monitor changes of the articular cartilage non-invasively and before gross morphological alterations appear.

Methods

Quantitative MR imaging has shown promising results with various imaging biomarkers such as T2 mapping, T1 rho and dGEMRIC demonstrating sensitivity in the detection of biochemical alterations within tissues of interest. However, acquiring accurate and clinically valuable quantitative data has proven challenging, and the reproducibility of the quantitative mapping technique and its values are essential. Although T2 mapping has been the focus in this discussion, all quantitative mapping techniques are subject to the same issues including variability in the imaging protocol, unloading and exercise, analysis, scanner and coil, calculation methods, and segmentation and registration concerns.

Results

The causes for variability between time points longitudinally in a patient, among patients, and among centres need to be understood further and the issues addressed.

Conclusions

The potential clinical applications of quantitative mapping are vast, but, before the clinical community can take full advantage of this tool, it must be automated, standardized, validated, and have proven reproducibility prior to its implementation into the standard clinical care routine.

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Title: Quantitative MRI in the evaluation of articular cartilage health: reproducibility and variability with a focus on T2 mapping
Authors: Rachel K. Surowiec
Erin P. Lucas
Charles P. Ho
Publication date: 01-06-2014
Publisher: Springer Berlin Heidelberg
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2014
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-013-2714-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quantitative MRI in the evaluation of articular cartilage health: reproducibility and variability with a focus on T2 mapping

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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