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Knee Surgery, Sports Traumatology, Arthroscopy

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Open Access 01-08-2013 | Experimental study

Nutrition and degeneration of articular cartilage

Authors: Yuze Wang, Lei Wei, Lingyuan Zeng, Dongdong He, Xiaochun Wei

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 8/2013

Abstract

Purpose

To determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration.

Methods

Ninety-five-month-old male rabbits were randomly divided into 5 groups according to sources of nutrition: SFBM-both; BM-only; SF-only; None-SFBM; and Free plug (unrestricted). Nutrition to 4-mm-diameter cylindrical osteochondral plugs created on the trochlea of the distal femurs was obstructed by Polyvinyl Chloride (PVC) cap. Cartilage changes were assessed after 4, 8, and 12 weeks by histology, immunohistochemistry, and real-time PCR.

Results

Cartilage in the BM-only group suffered the greatest damage, followed by the None-SFBM and SF-only groups. Apoptosis was increased in the BM-only and None-SFBM groups compared with others. Cartilage was significantly thinner at all time points in the BM-only and None-SFBM groups when compared with SFBM-both and Free plug, whereas in the SF-only group, this difference occurred after 8 weeks. Compared with SFBM-both and Free plug, expression of collagen II and aggrecan mRNAs in all groups was decreased but MMP-3 increased, respectively.

Conclusion

Our data indicate that SF-derived nutrition is the dominant source of sustenance for adult cartilage structure and function. Cartilage damage is observed when the only nutrition source is the BM.

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Title: Nutrition and degeneration of articular cartilage
Authors: Yuze Wang
Lei Wei
Lingyuan Zeng
Dongdong He
Xiaochun Wei
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 8/2013
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-012-1977-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nutrition and degeneration of articular cartilage

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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