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Knee Surgery, Sports Traumatology, Arthroscopy

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Open Access 01-03-2011 | Knee

Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 3/2011

Abstract

Purpose

To evaluate the long-term effects of implantation of a biodegradable polymer meniscus implant on articular cartilage degeneration and compare this to articular cartilage degeneration after meniscectomy.

Methods

Porous polymer polycaprolacton-based polyurethane meniscus implants were implanted for 6 or 24 months in the lateral compartment of Beagle dog knees. Contralateral knees were meniscectomized, or left intact and served as controls. Articular cartilage degeneration was evaluated in detail using India ink staining, routine histology, immunochemistry for denatured (Col2-¾M) and cleaved (Col2-¾C_short) type II collagen, Mankin’s grading system, and cartilage thickness measurements.

Results

Histologically, fibrillation and substantial immunohistochemical staining for both denatured and cleaved type II collagen were found in all three treatment groups. The cartilage of the three groups showed identical degradation patterns. In the 24 months implant group, degradation appeared to be more severe when compared to the 6 months implant group and meniscectomy group. Significantly more cartilage damage (India ink staining, Mankin’s grading system, and cartilage thickness measurements) was found in the 24 months implant group compared to the 6 months implant group and meniscectomy group.

Conclusion

Degradation of the cartilage matrix was the result of both mechanical overloading as well as localized cell-mediated degradation. The degeneration patterns were highly variable between animals. Clinical application of a porous polymer implant for total meniscus replacement is not supported by this study.

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Title: Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant
Publication date: 01-03-2011
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 3/2011
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-010-1244-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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