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01-09-2018 | Editorial

MAP of 65: target of the past?

Authors: Pierre Asfar, Peter Radermacher, Marlies Ostermann

Published in: Intensive Care Medicine | Issue 9/2018

Excerpt

Septic shock is defined as sepsis with hypotension refractory to fluid challenge and requiring vasopressor support combined with an increase in arterial lactate reflecting impaired cellular energy metabolism and dysoxia. The use of vasoactive drugs to restore mean arterial pressure (MAP) is strongly recommended by the Surviving Sepsis Campaign [1] and the Task Force of the European Society of Intensive Care Medicine (ESICM) on circulatory shock management and monitoring [2]. …

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Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, Jaeschke R, Mebazaa A, Pinsky MR, Teboul JL et al (2014) Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 40(12):1795–1815CrossRefPubMedPubMedCentral

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Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N et al (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370(17):1583–1593CrossRefPubMed

Lamontagne F, Meade MO, Hebert PC, Asfar P, Lauzier F, Seely AJ, Day AG, Mehta S, Muscedere J, Bagshaw SM et al (2016) Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentrepilot randomized controlled trial. Intensive Care Med 42(4):542–550CrossRefPubMed

Maheshwari K, Nathanson BH, Munson SH, Khangulov V, Stevens M, Badani H, Khanna AK, Sessler DI (2018) The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients. Intensive Care Med 44:857–867. https://doi.org/10.1007/s00134-018-5218-5 CrossRefPubMedCentral

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10.

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11.

Ostermann M, Hall A, Crichton S (2017) Low mean perfusion pressure is a risk factor for progression of acute kidney injury in critically ill patients—a retrospective analysis. BMC Nephrol 18(1):151CrossRefPubMedPubMedCentral

Title: MAP of 65: target of the past?
Authors: Pierre Asfar
Peter Radermacher
Marlies Ostermann
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 9/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5292-8

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