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01-09-2017 | Research Agenda

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

Authors: Matteo Bassetti, Jose Garnacho-Montero, Thierry Calandra, Bartjan Kullberg, George Dimopoulos, Elie Azoulay, Arunaloke Chakrabarti, Daniel Kett, Cristobal Leon, Luis Ostrosky-Zeichner, Maurizio Sanguinetti, Jean-Francois Timsit, Malcom D. Richardson, Andrew Shorr, Oliver A. Cornely

Published in: Intensive Care Medicine | Issue 9/2017

Abstract

Purpose

To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting.

Methods

A systematic review of the medical literature taking account of national and international guidelines and expert opinion.

Results

Severe invasive fungal infections (IFIs) are becoming increasingly frequent in critically ill patients. Approximately 80% of IFIs are due to Candida spp. and 0.3–19% to Aspergillus spp. Recent observations emphasize the necessity of building a worldwide sentinel network to monitor the emergence of new fungal species and changes in susceptibility. Robust data on the attributable mortality are essential for the design of clinical studies with mortality endpoints. Although early antifungal therapy for Candida has been recommended in patients with risk factors, sepsis of unknown cause, and positive Candida serum biomarkers [β-1 → 3-d-glucan (BDG) and Candida albicans germ tube antibody (CAGTA)], its usefulness and influence on outcome need to be confirmed. Future studies may specifically address the optimal diagnostic and therapeutic strategies for patients with abdominal candidiasis. Better knowledge of the pharmacokinetics of antifungal molecules and tissue penetration is a key issue for intensivists. Regarding invasive aspergillosis, further investigation is needed to determine its incidence in the ICU, its relationship with influenza outbreaks, the clinical impact of rapid diagnosis, and the significance of combination treatment.

Conclusions

Fundamental questions regarding IFI have to be addressed over the next decade. The clinical studies described in this research agenda should provide a template and set priorities for the clinical investigations that need to be performed.

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Title: Intensive care medicine research agenda on invasive fungal infection in critically ill patients
Authors: Matteo Bassetti
Jose Garnacho-Montero
Thierry Calandra
Bartjan Kullberg
George Dimopoulos
Elie Azoulay
Arunaloke Chakrabarti
Daniel Kett
Cristobal Leon
Luis Ostrosky-Zeichner
Maurizio Sanguinetti
Jean-Francois Timsit
Malcom D. Richardson
Andrew Shorr
Oliver A. Cornely
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 9/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-017-4731-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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