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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2013

Open Access 01-03-2013 | Year in Review 2012

Year in review in Intensive Care Medicine 2012. II: Pneumonia and infection, sepsis, coagulation, hemodynamics, cardiovascular and microcirculation, critical care organization, imaging, ethics and legal issues

Authors: Massimo Antonelli, Marc Bonten, Maurizio Cecconi, Jean Chastre, Giuseppe Citerio, Giorgio Conti, J. Randall Curtis, Goran Hedenstierna, Michael Joannidis, Duncan Macrae, Salvatore M. Maggiore, Jordi Mancebo, Alexandre Mebazaa, Jean-Charles Preiser, Patricia Rocco, Jean-François Timsit, Jan Wernerman, Haibo Zhang

Published in: Intensive Care Medicine | Issue 3/2013

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Excerpt

Different pathogens, variable virulence in different strains of microorganisms, increasing age, and underlying diseases undoubtedly have an important impact on community-acquired pneumonia (CAP) morbidity and mortality, but genetic variability affecting the host response may also influence susceptibility and outcome [1]. This is why Martin-Loeches and colleagues [2] assessed the genetic variability at IL6 in a large cohort of 1,227 white Spanish patients with CAP, of whom 306 had pneumococcal CAP (P-CAP). In patients with P-CAP multivariate analysis adjusted for age, gender, co-morbidity, hospital of origin, and severity showed that the IL6 −174 GG genotype was protective against the development of ARDS, septic shock, and multiple organ dysfunction syndrome. This effect was higher than that observed in patients with CAP, irrespective of the causal pathogen involved. …
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Metadata
Title
Year in review in Intensive Care Medicine 2012. II: Pneumonia and infection, sepsis, coagulation, hemodynamics, cardiovascular and microcirculation, critical care organization, imaging, ethics and legal issues
Authors
Massimo Antonelli
Marc Bonten
Maurizio Cecconi
Jean Chastre
Giuseppe Citerio
Giorgio Conti
J. Randall Curtis
Goran Hedenstierna
Michael Joannidis
Duncan Macrae
Salvatore M. Maggiore
Jordi Mancebo
Alexandre Mebazaa
Jean-Charles Preiser
Patricia Rocco
Jean-François Timsit
Jan Wernerman
Haibo Zhang
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2804-9

Other articles of this Issue 3/2013

Intensive Care Medicine 3/2013 Go to the issue

Correspondence

Energy target for individualized ICU nutrition: reply to Franch-Arcas and Gonzalez-Sánchez

From the Inside

The winter steppe (fragments)

Original

Rising serum sodium levels are associated with a concurrent development of metabolic alkalosis in critically ill patients

Correspondence

Accuracy of urine NGAL commercial assays in critically ill patients

Original

Increased long-term mortality with plasma transfusion after coronary artery bypass surgery

Original

SuPAR and PAI-1 in critically ill, mechanically ventilated patients