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01-05-2010 | Pediatric Brief Report

Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates

Authors: Kosmas Sarafidis, Vasiliki Soubasi-Griva, Kaliopi Piretzi, Agathi Thomaidou, Eleni Agakidou, Anna Taparkou, Elisavet Diamanti, Vasiliki Drossou-Agakidou

Published in: Intensive Care Medicine | Issue 5/2010

Abstract

Objective

To assess the value of serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for early diagnosis of late-onset sepsis (LOS) in neonates, compared with interleukin-6 (IL-6).

Design and setting

Prospective, observational study in a single, level III neonatal intensive care unit of a university hospital.

Patients

Fifty-two preterm and term neonates evaluated for suspected LOS were studied. Neonates were classified into two groups: infected [confirmed sepsis (n = 22) and possible sepsis (n = 9)] and noninfected neonates (n = 21).

Measurements and results

Serum sTREM-1 and IL-6 were measured (enzyme-linked immunosorbent assays) when signs suggestive of sepsis emerged. Infected neonates had significantly higher sTREM-1 (p = 0.004) and IL-6 (p < 0.0001) than noninfected neonates. Receiver operating characteristic (ROC) curve analysis resulted in significant areas under the curve (AUC) for both sTREM-1 (AUC = 0.733, p = 0.005) and IL-6 (AUC = 0.892, p = 0.001) for identification of infected neonates, with the difference between the two AUC not being significant. Further analysis documented acceptable diagnostic performance of sTREM-1 and IL-6, which was not improved, however, when the two markers were combined.

Conclusions

Serum sTREM-1 increases in infected neonates. Diagnostic accuracy of sTREM-1 either alone or in combination with IL-6 is not better than that of IL-6.

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Title: Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates
Authors: Kosmas Sarafidis
Vasiliki Soubasi-Griva
Kaliopi Piretzi
Agathi Thomaidou
Eleni Agakidou
Anna Taparkou
Elisavet Diamanti
Vasiliki Drossou-Agakidou
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-1819-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

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