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01-03-2010 | Year in Review 2009

Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching

Authors: Massimo Antonelli, Elie Azoulay, Marc Bonten, Jean Chastre, Giuseppe Citerio, Giorgio Conti, Daniel De Backer, François Lemaire, Herwig Gerlach, Goran Hedenstierna, Michael Joannidis, Duncan Macrae, Jordi Mancebo, Salvatore M. Maggiore, Alexandre Mebazaa, Jean-Charles Preiser, Jerôme Pugin, Jan Wernerman, Haibo Zhang

Published in: Intensive Care Medicine | Issue 3/2010

Excerpt

Delirium is associated with prolonged intensive care unit (ICU) stay: its early recognition, treatment and prevention are becoming increasingly important. Scales and evaluation tools for delirium are becoming more diffuse, but a universal tool has not been defined yet, and probably delirium underrating still permeates the ICU environment. Spronk [1] investigated, during daily care, intensivists’ and ICU nurses’ skills in identifying the presence of delirium in ICU patients. In a 3-month period, all patients in the ICU for more than 48 h were screened daily for delirium both by attending intensivists and nurses. The Confusion Assessment Method for the ICU (CAM-ICU) was used as a screening instrument for delirium. During the study period, 46 patients (30 male, 16 female; median age 73 years) with an ICU stay of 6 days (range 4–11) were evaluated. CAM-ICU scores were obtained during 425 patient days. Considering the CAM-ICU as the reference standard, delirium occurred in 50% of the patients with a duration of 3 days (range 1–9). Days with delirium were poorly recognized by doctors (sensitivity 28.0%; specificity 100%) and ICU nurses (sensitivity 34.8%; specificity 98.3%). Recognition did not differ between hypoactive or active status of the patients involved. Delirium is severely underrecognized in the ICU in daily care. These data indicated that more attention should be paid to the implementation of a validated delirium-screening instrument during daily ICU care. …

Spronk PE, Riekerk B, Hofhuis J, Rommes JH (2009) Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med 35:1276–1280CrossRefPubMed

Pandharipande PP, Morandi A, Adams JR, Girard TD, Thompson JL, Shintani AK, Ely EW (2009) Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med 35:1886–1892CrossRefPubMed

Myhren H, Toien K, Ekeberg O, Karlsson S, Sandvik L, Stokland O (2009) Patients’ memory and psychological distress after ICU stay compared with expectations of the relatives. Intensive Care Med 35:2078–2086

Figueroa-Ramos MI, Arroyo-Novoa CM, Lee KA, Padilla G, Puntillo KA (2009) Sleep and delirium in ICU patients: a review of mechanisms and manifestations. Intensive Care Med 35:781–795CrossRefPubMed

Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM (2009) Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 35:796–809CrossRefPubMed

Sena MJ, Rivers RM, Muizelaar JP, Battistella FD, Utter GH (2009) Transfusion practices for acute traumatic brain injury: a survey of physicians at US trauma centers. Intensive Care Med 35:480–488CrossRefPubMed

Lavinio A, Rasulo FA, De Peri E, Czosnyka M, Latronico N (2009) The relationship between the intracranial pressure-volume index and cerebral autoregulation. Intensive Care Med 35:546–549CrossRefPubMed

Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, Grimaud D, Leverve X (2009) Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med 35:471–479CrossRefPubMed

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10.

Hough CL, Steinberg KP, Taylor Thompson B, Rubenfeld GD, Hudson LD (2009) Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med 35:63–68CrossRefPubMed

11.

Herridge MS (2009) Building consensus on ICU-acquired weakness. Intensive Care Med 35:1–3CrossRefPubMed

12.

Kesler SM, Sprenkle MD, David WS, Leatherman JW (2009) Severe weakness complicating status asthmaticus despite minimal duration of neuromuscular paralysis. Intensive Care Med 35:157–160CrossRefPubMed

13.

Pease S, Bouadma L, Kermarrec N, Schortgen F, Regnier B, Wolff M (2009) Early organ dysfunction course, cooling time and outcome in classic heatstroke. Intensive Care Med 35:1454–1458CrossRefPubMed

14.

Osman D, Monnet X, Castelain V, Anguel N, Warszawski J, Teboul JL, Richard C (2009) Incidence and prognostic value of right ventricular failure in acute respiratory distress syndrome. Intensive Care Med 35:69–76CrossRefPubMed

15.

Mekontso Dessap A, Charron C, Devaquet J, Aboab J, Jardin F, Brochard L, Vieillard-Baron A (2009) Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med 35:1850–1858CrossRefPubMed

16.

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17.

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18.

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19.

Marchick MR, Kline JA, Jones AE (2009) The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Med 35:1261–1264CrossRefPubMed

20.

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21.

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22.

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23.

Lefrant JY, De Backer D (2009) Can we use pulse pressure variations to predict fluid responsiveness in patients with ARDS? Intensive Care Med 35:966–968CrossRefPubMed

24.

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25.

Jabot J, Teboul JL, Richard C, Monnet X (2009) Passive leg raising for predicting fluid responsiveness: importance of the postural change. Intensive Care Med 35:85–90CrossRefPubMed

26.

Squara P, Cecconi M, Rhodes A, Singer M, Chiche JD (2009) Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med 35:1801–1808CrossRefPubMed

27.

Cecconi M, Dawson D, Grounds RM, Rhodes A (2009) Lithium dilution cardiac output measurement in the critically ill patient: determination of precision of the technique. Intensive Care Med 35:498–504CrossRefPubMed

28.

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29.

Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34:17–60CrossRefPubMed

30.

Mesquida J, Masip J, Gili G, Artigas A, Baigorri F (2009) Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients. Intensive Care Med 35:1106–1109CrossRefPubMed

31.

Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM (2008) Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34:2210–2217CrossRefPubMed

32.

den Uil CA, Caliskan K, Lagrand WK, van der Ent M, Jewbali LS, van Kuijk JP, Spronk PE, Simoons ML (2009) Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure. Intensive Care Med 35:1893–1899CrossRef

33.

Dubin A, Pozo MO, Ferrara G, Murias G, Martins E, Canullan C, Canales HS, Kanoore Edul VS, Estenssoro E, Ince C (2009) Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 35:556–564CrossRefPubMed

34.

Jhanji S, Lee C, Watson D, Hinds C, Pearse RM (2009) Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med 35:671–677CrossRefPubMed

35.

Vieillard-Baron A, Charron C, Chergui K, Peyrouset O, Jardin F (2006) Bedside echocardiographic evaluation of hemodynamics in sepsis: is a qualitative evaluation sufficient? Intensive Care Med 32:1547–1552CrossRefPubMed

36.

Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM (2009) Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med 35:1761–1766CrossRefPubMed

37.

Hartog C, Reinhart K (2009) CONTRA: hydroxyethyl starch solutions are unsafe in critically ill patients. Intensive Care Med 35:1337–1342CrossRefPubMed

38.

Boldt J (2009) PRO: hydroxyethylstarch can be safely used in the intensive care patient–the renal debate. Intensive Care Med 35:1331–1336CrossRefPubMed

39.

Schabinski F, Oishi J, Tuche F, Luy A, Sakr Y, Bredle D, Hartog C, Reinhart K (2009) Effects of a predominantly hydroxyethyl starch (HES)-based and a predominantly non HES-based fluid therapy on renal function in surgical ICU patients. Intensive Care Med 35:1539–1547CrossRefPubMed

40.

Boldt J, Suttner S, Brosch C, Lehmann A, Rohm K, Mengistu A (2009) The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med 35:462–470CrossRefPubMed

41.

Morisaki H, Yajima S, Watanabe Y, Suzuki T, Yamamoto M, Katori N, Hashiguchi S, Takeda J (2009) Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. Intensive Care Med 35:129–135CrossRefPubMed

42.

Gnaegi A, Feihl F, Boulat O, Waeber B, Liaudet L (2009) Moderate hypercapnia exerts beneficial effects on splanchnic energy metabolism during endotoxemia. Intensive Care Med 35:1297–1304CrossRefPubMed

43.

Di Paola R, Menegazzi M, Mazzon E, Genovese T, Crisafulli C, Dal Bosco M, Zou Z, Suzuki H, Cuzzocrea S (2009) Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model. Intensive Care Med 35:687–697CrossRefPubMed

44.

Zanotti-Cavazzoni SL, Guglielmi M, Parrillo JE, Walker T, Dellinger RP, Hollenberg SM (2009) Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis. Intensive Care Med 35:748–754CrossRefPubMed

45.

Baumgart K, Simkova V, Wagner F, Weber S, Georgieff M, Radermacher P, Albuszies G, Barth E (2009) Effect of SOD-1 over-expression on myocardial function during resuscitated murine septic shock. Intensive Care Med 35:344–349CrossRefPubMed

46.

Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T (2008) High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats. Intensive Care Med 34:361–367CrossRefPubMed

47.

Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Koga H, Noguchi T (2009) Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. Intensive Care Med 35:1471–1478CrossRefPubMed

48.

Hagiwara S, Iwasaka H, Hasegawa A, Asai N, Noguchi T (2008) High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis. Intensive Care Med 34:1812–1819CrossRefPubMed

49.

Pugin J (2008) Dear SIRS, the concept of “alarmins” makes a lot of sense!. Intensive Care Med 34:218–221CrossRefPubMed

50.

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51.

Wolff S, Klatt S, Wolff JC, Wilhelm J, Fink L, Kaps M, Rosengarten B (2009) Endotoxin-induced gene expression differences in the brain and effects of iNOS inhibition and norepinephrine. Intensive Care Med 35:730–739CrossRefPubMed

52.

Sykora R, Chvojka J, Krouzecky A, Radej J, Karvunidis T, Varnerova V, Novak I, Matejovic M (2009) High versus standard-volume haemofiltration in hyperdynamic porcine peritonitis: effects beyond haemodynamics? Intensive Care Med 35:371–380CrossRefPubMed

53.

Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Muhl H, Boost KA, Hofstetter C (2009) Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med 35:1412–1419CrossRefPubMed

54.

Leendertse M, Willems RJ, Giebelen IA, Florquin S, van den Pangaart PS, Bonten MJ, van der Poll T (2009) Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis. Intensive Care Med 35:924–932CrossRefPubMed

55.

Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohe J, Lepape A, Ayala A, Monneret G (2009) Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 35:678–686CrossRefPubMed

56.

Ferrari F, Liu ZH, Lu Q, Becquemin MH, Louchahi K, Aymard G, Marquette CH, Rouby JJ (2008) Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med 34:1718–1723CrossRefPubMed

57.

Ferrari F, Lu Q, Girardi C, Petitjean O, Marquette CH, Wallet F, Rouby JJ (2009) Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa. Intensive Care Med 35:1792–1800CrossRefPubMed

58.

Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS (2009) A comparison of methods to identify open-lung PEEP. Intensive Care Med 35:740–747CrossRefPubMed

59.

Dellaca RL, Andersson Olerud M, Zannin E, Kostic P, Pompilio PP, Hedenstierna G, Pedotti A, Frykholm P (2009) Lung recruitment assessed by total respiratory system input reactance. Intensive Care Med 35:2164–2172

60.

Steimback PW, Oliveira GP, Rzezinski AF, Silva PL, Garcia CS, Rangel G, Morales MM, Lapa ESJR, Capelozzi VL, Pelosi P, Rocco PR (2009) Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury. Intensive Care Med 35:1120–1128CrossRefPubMed

61.

Pellicano A, Tingay DG, Mills JF, Fasulakis S, Morley CJ, Dargaville PA (2009) Comparison of four methods of lung volume recruitment during high frequency oscillatory ventilation. Intensive Care Med 35:1990–1998CrossRefPubMed

62.

Martinez-Caro L, Lorente JA, Marin-Corral J, Sanchez-Rodriguez C, Sanchez-Ferrer A, Nin N, Ferruelo A, de Paula M, Fernandez-Segoviano P, Barreiro E, Esteban A (2009) Role of free radicals in vascular dysfunction induced by high tidal volume ventilation. Intensive Care Med 35:1110–1119CrossRefPubMed

63.

Bueltmann M, Kong X, Mertens M, Yin N, Yin J, Liu Z, Koster A, Kuppe H, Kuebler WM (2009) Inhaled milrinone attenuates experimental acute lung injury. Intensive Care Med 35:171–178CrossRefPubMed

64.

Dyson A, Stidwill R, Taylor V, Singer M (2009) The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Med 35:1783–1791CrossRefPubMed

65.

Douzinas EE (2009) Progressive hemorrhage: administer oxygen or early resuscitation? Intensive Care Med 35:1664–1666CrossRefPubMed

66.

Hare GM, Liu E, Baker AJ, Mazer CD (2009) Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats. Intensive Care Med 35:1925–1933CrossRefPubMed

67.

Liu KX, Li YS, Huang WQ, Chen SQ, Wang ZX, Liu JX, Xia Z (2009) Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med 35:933–942CrossRefPubMed

68.

Krouzecky A, Chvojka J, Sykora R, Radej J, Karvunidis T, Novak I, Ruzicka J, Petrankova Z, Benes J, Bolek L, Matejovic M (2009) Regional cooling of the extracorporeal blood circuit: a novel anticoagulation approach for renal replacement therapy? Intensive Care Med 35:364–370CrossRefPubMed

69.

Bagshaw SM, Davenport A (2009) Cooling and reduced risk of clotting within the extracorporeal continuous renal replacement circuit. Intensive Care Med 35:195–197CrossRefPubMed

70.

Mouly S, Meune C, Bergmann JF (2009) Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4. Intensive Care Med 35:417–429CrossRefPubMed

71.

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72.

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73.

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74.

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75.

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76.

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77.

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78.

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79.

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81.

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82.

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83.

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84.

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Title: Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching
Authors: Massimo Antonelli
Elie Azoulay
Marc Bonten
Jean Chastre
Giuseppe Citerio
Giorgio Conti
Daniel De Backer
François Lemaire
Herwig Gerlach
Goran Hedenstierna
Michael Joannidis
Duncan Macrae
Jordi Mancebo
Salvatore M. Maggiore
Alexandre Mebazaa
Jean-Charles Preiser
Jerôme Pugin
Jan Wernerman
Haibo Zhang
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-1770-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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