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Intensive Care Medicine

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01-12-2008 | Original

The risk associated with hyperoncotic colloids in patients with shock

Authors: Frédérique Schortgen, Emmanuelle Girou, Nicolas Deye, Laurent Brochard, for the CRYCO Study Group

Published in: Intensive Care Medicine | Issue 12/2008

Abstract

Objective

Crystalloids, artificial and natural colloids have been opposed as representing different strategies for shock resuscitation, but it may be relevant to distinguish fluids based on their oncotic characteristics. This study assessed the risk of renal adverse events in patients with shock resuscitated using hypooncotic colloids, artificial hyperoncotic colloids, hyperoncotic albumin or crystalloids, according to physician’s choice.

Participants and setting

International prospective cohort study including 1,013 ICU patients needing fluid resuscitation for shock. Patients suffering from cirrhosis or receiving plasma were excluded.

Measurements and results

Influence of different types of colloids and crystalloids on the occurrence of renal events (twofold increase in creatinine or need for dialysis) and mortality was assessed using multivariate analyses and propensity score. Statistical adjustment was based on severity at the time of resuscitation, risks factor for renal failure, and on variables influencing physicians’ preferences regarding fluids. A renal event occurred in 17% of patients. After adjustment on potential confounding factors and on propensity score for the use of hyperoncotic colloids, the use of artificial hyperoncotic colloids [OR: 2.48 (1.24–4.97)] and hyperoncotic albumin [OR: 5.99 (2.75–13.08)] was significantly associated with occurrence of renal event. Overall ICU mortality was 27.1%. The use of hyperoncotic albumin was associated with an increased risk of ICU death [OR: 2.79 (1.42–5.47)].

Conclusions

This study suggests that harmful effects on renal function and outcome of hyperoncotic colloids may exist. Although an improper usage of these compounds and confounding factors cannot be ruled out, their use should be regarded with caution, especially because suitable alternatives exist.

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Title: The risk associated with hyperoncotic colloids in patients with shock
Authors: Frédérique Schortgen
Emmanuelle Girou
Nicolas Deye
Laurent Brochard
for the CRYCO Study Group
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 12/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1225-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The risk associated with hyperoncotic colloids in patients with shock

Abstract

Objective

Participants and setting

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Participants and setting

Measurements and results

Conclusions

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