Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 5/2008

01-05-2008 | Editorial

Ventilator-induced lung injury: another sign of aging?

Authors: Joan R. Badia, Niall D. Ferguson

Published in: Intensive Care Medicine | Issue 5/2008

Login to get access

Excerpt

Acute respiratory distress syndrome (ARDS) is, as its name implies, a syndromic clinical entity, which attempts to capture and characterize a specific type of inflammatory lung injury, reflected pathologically (at least in its early stages) by diffuse alveolar damage [1, 2]. ARDS is important because it can affect an extremely heterogeneous population and result from a wide variety of risk factors and conditions that can injure the lungs either directly or indirectly [3‐5]. In addition, ARDS is not a rare condition. Recent rigorous measurements reveal a high incidence, and it may affect as many as 16% of mechanically ventilated patients in an intensive care setting [6‐8]. The mortality from ARDS ranges from 30% to 60% depending on the specific patient mix and selection criteria, with most deaths resulting from multiple organ failure and sepsis [6‐10]. Patients who do survive frequently suffer reduced health-related quality of life that can persist for years after hospital discharge [11‐13]. …
Literature
1.
Katzenstein AL, Bloor CM, Leibow AA (1976) Diffuse alveolar damage: the role of oxygen, shock, and related factors. A review. Am J Pathol 85:209–228PubMed
2.
Tomashefski JF Jr (2000) Pulmonary pathology of acute respiratory distress syndrome. Clin Chest Med 21:435–466PubMedCrossRef
3.
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R (1994) The American–European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Resp Crit Care Med 149:818–824PubMed
4.
Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349PubMedCrossRef
5.
Hudson LD, Milberg JA, Anardi D, Maunder RJ (1995) Clinical risks for development of the acute respiratory distress syndrome. Am J Resp Crit Care Med 151:293–301PubMed
6.
Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685–1693PubMedCrossRef
7.
Bersten AD, Edibam C, Hunt T, Moran J (2002) Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian states. Am J Respir Crit Care Med 165:443–448PubMed
8.
Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, Frostell CG, Bonde J (1999) Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF Study Group. Am J Resp Crit Care Med 159:1849–1861PubMed
9.
Ferguson ND, Frutos-Vivar F, Esteban A, Anzueto A, Alía I, Brower RG, Stewart TE, Apezteguía C, González M, Soto L, Abroug F, Brochard L, Mechanical Ventilation International Study Group (2005) Airway pressures, tidal volumes and mortality in patients with the acute respiratory distress syndrome. Crit Care Med 33:21–30PubMedCrossRef
10.
Esteban A, Anzueto A, Frutos F, Alía I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguía C, Nightingale P, Arroliga AC, Tobin MJ, Mechanical Ventilation International Study Group (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation. A 28-day international study. JAMA 287:345–355PubMedCrossRef
11.
Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS, Canadian Critical Care Trials Group (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348:683–693PubMedCrossRef
12.
Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matté A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Resp Crit Care Med 174:538–544PubMedCrossRef
13.
Angus DC, Musthafa AA, Clermont G, Griffin MF, Linde-Zwirble WT, Dremsizov TT, Pinsky MR (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. Am J Resp Crit Care Med 163:1389–1394PubMed
14.
Milberg JA, Davis DR, Steinberg KP, Hudson LD (1995) Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983–1993. JAMA 273:306–309PubMedCrossRef
15.
Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP (2005) Causes and timing of death in patients with ARDS. Chest 128:525–532PubMedCrossRef
16.
The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef
17.
Sakr Y, Vincent JL, Reinhart K, Groeneveld J, Michalopoulos A, Sprung CL, Artigas A, Ranieri VM, Sepsis Occurrence in Acutely Ill Patients Investigators (2005) High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest 128:3098–3108PubMedCrossRef
18.
Villar J, Kacmarek RM, Perez-Mendez L, Aguirre-Jaime A (2006) A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 34:1311–1318PubMedCrossRef
19.
Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Resp Crit Care Med 157:294–323PubMed
20.
Chiumello D, Pristine G, Slutsky AS (1999) Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 160:109–116PubMed
21.
Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS (2003) Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289:2104–2112PubMedCrossRef
22.
Gurkan OU, O'Donnell C, Brower R, Ruckdeschel E, Becker PM (2003) Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol 285:L710–L718PubMed
23.
Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA (2002) Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med 165:242–249PubMed
24.
Lecuona E, Saldias F, Comellas A, Ridge K, Guerrero C, Sznajder J (1999) Ventilator-associated lung injury decreases lung ability to clear edema in rats. Am J Respir Crit Care Med 159:603–609PubMed
25.
Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61PubMedCrossRef
26.
Nin N, Lorente JA, De Paula M, Fernández-Segoviano P, Peñuelas O, Sánchez-Ferrer A, Martínez-Caro L, Esteban A (2008) Aging increases the susceptibility to injurious mechanical ventilation. Intensive Care Med DOI 10.​1007/​s00134-007-0960-0
27.
Nin N, Lorente JA, De Paula M, El Assar M, Vallejo S, Peñuelas O, Fernández-Segoviano P, Ferruelo A, Sánchez-Ferrer A, Esteban A (2008) Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med DOI 10.​1007/​s00134-007-0959-6
28.
Malus E, Kim CH, Zhang H, Slutsky AS (2002) Setting tidal volume based on body weight may not be optimal in studies of ventilator induced lung injury. Am J Resp Crit Care Med 165:A787
29.
Gajic O, Frutos-Vivar F, Esteban A, Hubmayr RD, Anzueto A (2005) Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients. Intensive Care Med 31:922–926PubMedCrossRef
Metadata
Title
Ventilator-induced lung injury: another sign of aging?
Authors
Joan R. Badia
Niall D. Ferguson
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 5/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0961-z

Other articles of this Issue 5/2008

Intensive Care Medicine 5/2008 Go to the issue

Pediatric Original

Junctional ectopic tachycardia after surgery for congenital heart disease in children

Physiological and Technical Notes

Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong

Correspondence

A patient with an unusual aetiology of a severe ketoacidosis

Editorial

ICU-acquired infections and Sepsis: More of a deadly duo

Correspondence

Sophisticated biomarkers for community-acquired pneumonia severity asessment: gadgets or useful tools?

Correspondence

Severity of illness assessment in community-acquired pneumonia