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Published in: Intensive Care Medicine 5/2008

01-05-2008 | Physiological and Technical Notes

Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong

Authors: Claudio Ronco, Andrew A. House, Mikko Haapio

Published in: Intensive Care Medicine | Issue 5/2008

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Abstract

Background

The term “cardiorenal syndrome” has generally been reserved for declining renal function in the setting of advanced congestive heart failure. Considering the complex and bi-directional relationship between the heart and the kidneys, we postulate refining the definition to recognize the symbiotic nature of these organs.

Discussion

We divide the cardiorenal syndrome into five subtypes: type I, acute cardiorenal syndrome; type II, chronic cardiorenal syndrome; type III, acute renocardiac syndrome; type IV, chronic renocardiac syndrome; and type V, secondary cardiorenal syndrome.

Conclusions

As early recognition of dysfunction in one organ may prove important in mitigating the spiral of co-dysfunction in both, the need for early and treatment-guiding biomarkers, along with their characteristics, are also discussed.
Literature
1.
go back to reference Yancy CW, Lopatin M, Stevenson LW, De Marco T, Fonarow GC, ADHERE Scientific Advisory Committee and Investigators (2006) Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database. J Am Coll Cardiol 47:76–84PubMedCrossRef Yancy CW, Lopatin M, Stevenson LW, De Marco T, Fonarow GC, ADHERE Scientific Advisory Committee and Investigators (2006) Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database. J Am Coll Cardiol 47:76–84PubMedCrossRef
2.
go back to reference Stevenson LW, Nohria A, Mielniczuk L (2005) Torrent or torment from the tubules? Challenge of the cardiorenal connections. J Am Coll Cardiol 45:2004–2007PubMedCrossRef Stevenson LW, Nohria A, Mielniczuk L (2005) Torrent or torment from the tubules? Challenge of the cardiorenal connections. J Am Coll Cardiol 45:2004–2007PubMedCrossRef
3.
go back to reference Kimmenade RR van, Januzzi JL Jr, Baggish AL, Lainchbury JG, Bayes-Genis A, Richards AM, Pinto YM (2006) Amino-terminal pro-brain natriuretic peptide, renal function, and outcomes in acute heart failure: redefining the cardiorenal interaction? J Am Coll Cardiol 48:1621–1627CrossRef Kimmenade RR van, Januzzi JL Jr, Baggish AL, Lainchbury JG, Bayes-Genis A, Richards AM, Pinto YM (2006) Amino-terminal pro-brain natriuretic peptide, renal function, and outcomes in acute heart failure: redefining the cardiorenal interaction? J Am Coll Cardiol 48:1621–1627CrossRef
4.
go back to reference Bongartz LG, Cramer MJ, Doevendans PA, Joles JA, Braam B (2005) The severe cardiorenal syndrome: ‘Guyton revisited’. Eur Heart J 26:11–17PubMedCrossRef Bongartz LG, Cramer MJ, Doevendans PA, Joles JA, Braam B (2005) The severe cardiorenal syndrome: ‘Guyton revisited’. Eur Heart J 26:11–17PubMedCrossRef
5.
go back to reference Tsagalis G, Zerefos S, Zerefos N (2007) Cardiorenal syndrome at different stages of chronic kidney disease. Int J Artif Organs 30:564–576PubMed Tsagalis G, Zerefos S, Zerefos N (2007) Cardiorenal syndrome at different stages of chronic kidney disease. Int J Artif Organs 30:564–576PubMed
6.
go back to reference Ishani A, Grandits GA, Grimm RH, Svendsen KH, Collins AJ, Prineas RJ, Neaton JD (2006) Association of single measurements of dipstick proteinuria, estimated glomerular filtration rate, and hematocrit with 25-year incidence of end-stage renal disease in the multiple risk factor intervention trial. J Am Soc Nephrol 17:1444–1452PubMedCrossRef Ishani A, Grandits GA, Grimm RH, Svendsen KH, Collins AJ, Prineas RJ, Neaton JD (2006) Association of single measurements of dipstick proteinuria, estimated glomerular filtration rate, and hematocrit with 25-year incidence of end-stage renal disease in the multiple risk factor intervention trial. J Am Soc Nephrol 17:1444–1452PubMedCrossRef
7.
go back to reference Silverberg DS, Wexler D, Iaina A, Steinbruch S, Wollman Y, Schwartz D (2006) Anemia, chronic renal disease and congestive heart failure-the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists. Int Urol Nephrol 38:295–310PubMedCrossRef Silverberg DS, Wexler D, Iaina A, Steinbruch S, Wollman Y, Schwartz D (2006) Anemia, chronic renal disease and congestive heart failure-the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists. Int Urol Nephrol 38:295–310PubMedCrossRef
8.
go back to reference Domanovits H, Schillinger M, Mullner M, Thoennissen J, Sterz F, Zeiner A, Druml W (2001) Acute renal failure after successful cardiopulmonary resuscitation. Intensive Care Med 27:1194–1199PubMedCrossRef Domanovits H, Schillinger M, Mullner M, Thoennissen J, Sterz F, Zeiner A, Druml W (2001) Acute renal failure after successful cardiopulmonary resuscitation. Intensive Care Med 27:1194–1199PubMedCrossRef
9.
go back to reference Neuhofer W, Pittrow D (2006) Role of endothelin and endothelin receptor antagonists in renal disease. Eur J Clin Invest 36 Suppl 3:78–88PubMedCrossRef Neuhofer W, Pittrow D (2006) Role of endothelin and endothelin receptor antagonists in renal disease. Eur J Clin Invest 36 Suppl 3:78–88PubMedCrossRef
10.
go back to reference Kuitunen A, Vento A, Suojaranta-Ylinen R, Pettila V (2006) Acute renal failure after cardiac surgery: evaluation of the RIFLE classification. Ann Thorac Surg 81:542–546PubMedCrossRef Kuitunen A, Vento A, Suojaranta-Ylinen R, Pettila V (2006) Acute renal failure after cardiac surgery: evaluation of the RIFLE classification. Ann Thorac Surg 81:542–546PubMedCrossRef
11.
go back to reference Bellomo R, Kellum JA, Ronco C (2007) Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria. Intensive Care Med 33:409–413PubMedCrossRef Bellomo R, Kellum JA, Ronco C (2007) Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria. Intensive Care Med 33:409–413PubMedCrossRef
12.
go back to reference Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT (2002) BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105:1348–1353PubMedCrossRef Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT (2002) BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105:1348–1353PubMedCrossRef
13.
go back to reference Komajda M, Anker SD, Charlesworth A, Okonko D, Metra M, Di Lenarda A, Remme W, Moullet C, Swedberg K, Cleland JG, Poole-Wilson PA (2006) The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J 27:1440–1446PubMedCrossRef Komajda M, Anker SD, Charlesworth A, Okonko D, Metra M, Di Lenarda A, Remme W, Moullet C, Swedberg K, Cleland JG, Poole-Wilson PA (2006) The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J 27:1440–1446PubMedCrossRef
14.
go back to reference Struthers AD, MacDonald TM (2004) Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res 61:663–670PubMedCrossRef Struthers AD, MacDonald TM (2004) Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res 61:663–670PubMedCrossRef
15.
go back to reference Onozato ML, Tojo A, Kobayashi N, Goto A, Matsuoka H, Fujita T (2007) Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant 22:1314–1322PubMedCrossRef Onozato ML, Tojo A, Kobayashi N, Goto A, Matsuoka H, Fujita T (2007) Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant 22:1314–1322PubMedCrossRef
16.
go back to reference Spanaus KS, Kronenberg F, Ritz E, Schlapbach R, Fliser D, Hersberger M, Kollerits B, Konig P, von Eckardstein A, Mild-to-Moderate Kidney Disease Study Group (2007) B-type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: the Mild-to-Moderate Kidney Disease Study. Clin Chem 53:1264–1272PubMedCrossRef Spanaus KS, Kronenberg F, Ritz E, Schlapbach R, Fliser D, Hersberger M, Kollerits B, Konig P, von Eckardstein A, Mild-to-Moderate Kidney Disease Study Group (2007) B-type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: the Mild-to-Moderate Kidney Disease Study. Clin Chem 53:1264–1272PubMedCrossRef
17.
go back to reference Kelly KJ (2006) Acute renal failure: much more than a kidney disease. Semin Nephrol 26:105–113PubMedCrossRef Kelly KJ (2006) Acute renal failure: much more than a kidney disease. Semin Nephrol 26:105–113PubMedCrossRef
18.
go back to reference Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL (2001) Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 103:2055–2059PubMed Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL (2001) Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 103:2055–2059PubMed
19.
go back to reference Berl T, Henrich W (2006) Kidney-heart interactions: epidemiology, pathogenesis, and treatment. Clin J Am Soc Nephrol 1:8–18PubMedCrossRef Berl T, Henrich W (2006) Kidney-heart interactions: epidemiology, pathogenesis, and treatment. Clin J Am Soc Nephrol 1:8–18PubMedCrossRef
20.
go back to reference Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, McAlister F, Garg AX (2006) Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 17:2034–2047PubMedCrossRef Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, McAlister F, Garg AX (2006) Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 17:2034–2047PubMedCrossRef
21.
go back to reference Fort J (2005) Chronic renal failure: a cardiovascular risk factor. Kidney Int Suppl 99:S25–S29 Fort J (2005) Chronic renal failure: a cardiovascular risk factor. Kidney Int Suppl 99:S25–S29
22.
go back to reference Schiffrin EL, Lipman ML, Mann JF (2007) Chronic kidney disease: effects on the cardiovascular system. Circulation 116:85–97PubMedCrossRef Schiffrin EL, Lipman ML, Mann JF (2007) Chronic kidney disease: effects on the cardiovascular system. Circulation 116:85–97PubMedCrossRef
24.
go back to reference Movilli E, Feliciani A, Camerini C, Brunori G, Zubani R, Scolari F, Parrinello G, Cancarini GC (2005) A high calcium-phosphate product is associated with high C-reactive protein concentrations in hemodialysis patients. Nephron Clin Pract 101:c161–c167PubMedCrossRef Movilli E, Feliciani A, Camerini C, Brunori G, Zubani R, Scolari F, Parrinello G, Cancarini GC (2005) A high calcium-phosphate product is associated with high C-reactive protein concentrations in hemodialysis patients. Nephron Clin Pract 101:c161–c167PubMedCrossRef
25.
go back to reference Periyasamy SM, Chen J, Cooney D, Carter P, Omran E, Tian J, Priyadarshi S, Bagrov A, Fedorova O, Malhotra D, Xie Z, Shapiro JI (2001) Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function. Kidney Int 60:2367–2376PubMedCrossRef Periyasamy SM, Chen J, Cooney D, Carter P, Omran E, Tian J, Priyadarshi S, Bagrov A, Fedorova O, Malhotra D, Xie Z, Shapiro JI (2001) Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function. Kidney Int 60:2367–2376PubMedCrossRef
26.
go back to reference Groenning BA, Raymond I, Hildebrandt PR, Nilsson JC, Baumann M, Pedersen F (2004) Diagnostic and prognostic evaluation of left ventricular systolic heart failure by plasma N-terminal pro-brain natriuretic peptide concentrations in a large sample of the general population. Heart 90:297–303PubMedCrossRef Groenning BA, Raymond I, Hildebrandt PR, Nilsson JC, Baumann M, Pedersen F (2004) Diagnostic and prognostic evaluation of left ventricular systolic heart failure by plasma N-terminal pro-brain natriuretic peptide concentrations in a large sample of the general population. Heart 90:297–303PubMedCrossRef
27.
go back to reference Carr SJ, Bavanandan S, Fentum B, Ng L (2005) Prognostic potential of brain natriuretic peptide (BNP) in predialysis chronic kidney disease patients. Clin Sci (Lond) 109:75–82CrossRef Carr SJ, Bavanandan S, Fentum B, Ng L (2005) Prognostic potential of brain natriuretic peptide (BNP) in predialysis chronic kidney disease patients. Clin Sci (Lond) 109:75–82CrossRef
28.
go back to reference Apple FS, Murakami MM, Pearce LA, Herzog CA (2004) Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death. Clin Chem 50:2279–2285PubMedCrossRef Apple FS, Murakami MM, Pearce LA, Herzog CA (2004) Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death. Clin Chem 50:2279–2285PubMedCrossRef
29.
go back to reference Wang AY, Lam CW, Yu CM, Wang M, Chan IH, Zhang Y, Lui SF, Sanderson JE (2007) N-terminal pro-brain natriuretic peptide: an independent risk predictor of cardiovascular congestion, mortality, and adverse cardiovascular outcomes in chronic peritoneal dialysis patients. J Am Soc Nephrol 18:321–330PubMedCrossRef Wang AY, Lam CW, Yu CM, Wang M, Chan IH, Zhang Y, Lui SF, Sanderson JE (2007) N-terminal pro-brain natriuretic peptide: an independent risk predictor of cardiovascular congestion, mortality, and adverse cardiovascular outcomes in chronic peritoneal dialysis patients. J Am Soc Nephrol 18:321–330PubMedCrossRef
30.
go back to reference Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, MacKinnon RW, Li L, Balakrishnan VS, Pereira BJ, Bonventre JV, Jaber BL (2007) Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 18:904–912PubMedCrossRef Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, MacKinnon RW, Li L, Balakrishnan VS, Pereira BJ, Bonventre JV, Jaber BL (2007) Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 18:904–912PubMedCrossRef
31.
go back to reference Honore PM, Joannes-Boyau O, Boer W (2007) The early biomarker of acute kidney injury: in search of the Holy Grail. Intensive Care Med 33:1866–1868PubMedCrossRef Honore PM, Joannes-Boyau O, Boer W (2007) The early biomarker of acute kidney injury: in search of the Holy Grail. Intensive Care Med 33:1866–1868PubMedCrossRef
32.
go back to reference Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534–2543PubMedCrossRef Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534–2543PubMedCrossRef
33.
go back to reference Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231–1238PubMedCrossRef Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231–1238PubMedCrossRef
34.
go back to reference Herget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115–1122PubMedCrossRef Herget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115–1122PubMedCrossRef
Metadata
Title
Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong
Authors
Claudio Ronco
Andrew A. House
Mikko Haapio
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 5/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1017-8

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