Top

Published in:

01-11-2007 | Editorial

The early biomarker of acute kidney injury: in search of the Holy Grail

Authors: Patrick M. Honore, Olivier Joannes-Boyau, Willem Boer

Published in: Intensive Care Medicine | Issue 11/2007

Excerpt

Acute kidney injury (AKI) is a major clinical problem with rising incidence and a high mortality rate resulting in four million attributable deaths worldwide on a yearly basis [1]. The lack of an early and effective biomarker results in a significant delay in initiating appropriate therapy [2]. A revolutionary step was taken in cardiology when various early biological markers for cardiac damage became available (including troponins), enabling the clinician to instigate early and effective treatment for acute coronary disease [3]. …

Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators (2005) Acute renal failure in critically ill patients: a multinational multicenter study. JAMA 294:813–818PubMedCrossRef

Herget-Rosenthal S, Marggraf G, Hüsing J, Göring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115–1122PubMedCrossRef

Khan IA, Wattanasuwan N (2005) Role of biochemical markers in diagnosis of myocardial infarction. Int J Cardiol 104:238–240PubMedCrossRef

Devarajan P (2006) Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 15:2756–2758

Herrera-Gutierrez ME, Seller-Perez G, Banderas-Bravo E, Munoz-Bono J, Lebron-Gallardo M, Fernandez-Ortega J (2007) Replacement of 24-hour creatinine clearance by 2-hour creatinine clearance in intensive care units. A single-center study. Intensive Care Med DOI 10.1007/s00134-007-0745-5

Bellomo R, Kellum JA, Ronco C (2004) Defining acute renal failure: physiological principles. Intensive Care Med 30:33–37PubMedCrossRef

Devarajan P (2007) Emerging biomarkers of acute kidney injury. Contrib Nephrol 156:203–212PubMedCrossRef

Han WK, Bonventre JV (2004) Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care 10:476–482PubMedCrossRef

Schrier RW (2004) Need to intervene in established acute renal failure. J Am Soc Nephrol 15:2756–2758PubMedCrossRef

10.

Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A (2005) Cystatin C as a marker of GFR – history, indications, and future research. Clin Biochem 38:1–8PubMedCrossRef

11.

Devarajan P, Mishra J, Supavekin S, Patterson LT, Potter SS (2003) Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics. Mol Genet Metab 80:365–376PubMedCrossRef

12.

Bagshaw S, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48:402–409PubMedCrossRef

13.

Schrier RW, Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351:159–169PubMedCrossRef

14.

Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2003) Neutrophil gelatinase-associated lipocain (NGAL): a novel urinary biomarker for ischemic injury. J Am Soc Nephrol 4:2534–2543CrossRef

15.

Delanaye P, Lambermont B, Chapelle JP, Gielen J, Gerard P, Rorive G (2004) Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Intensive Care Med 30:980–983PubMedCrossRef

16.

Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV (2002) Kidney injury molecule-1(KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 62:237–244PubMedCrossRef

17.

Parikh CR, Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly C, Dent C, Devarajan P, Edelstein CL (2006) Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int 70:199–203PubMedCrossRef

18.

Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005): Gelatinase-associated lipocain (NGAL) as a biomarker for acute renal injury following cardiac surgery. Lancet 365:1231–1238PubMedCrossRef

19.

Dharnidharka VR, Kwon C, Stevens G (2002) Serum cystatin C is superior to serum creatine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 40:221–226PubMedCrossRef

20.

Vandevoorde RG, Katlman TI, Ma Q, Kelly C, Mishra J, Dent CA, Mitsnefes MM, Devarajan P (2006) Serum NGAL and cystatin C as predictive biomarkers for acute kidney injury. J Am Soc Nephrol 17:404A

21.

Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barassch J, Edelstein CL, Devarajan P (2006) Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant 6:1639–1645PubMedCrossRef

22.

Golstein SL (2007) Kidney function assessment in the critically ill child: is it time to leave creatinine behind? Crit Care 11:141CrossRef

23.

Herrero-Morin JD, Malaga S, Fernandez N, Rey C, Dieguez MA, Solis G, Concha A, Medina A (2007) Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children. Crit Care 11:R59PubMedCrossRef

Title: The early biomarker of acute kidney injury: in search of the Holy Grail
Authors: Patrick M. Honore
Olivier Joannes-Boyau
Willem Boer
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 11/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0766-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The early biomarker of acute kidney injury: in search of the Holy Grail

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 11/2007

RIFLE classification can predict short-term prognosis in critically ill cirrhotic patients

Outcomes and prognostic factors in patients with head and neck cancer and severe acute illnesses

The polycompartment syndrome: towards an understanding of the interactions between different compartments!

The views of patients and relatives of what makes a good intensivist: a European survey

Reply to the comment by Dr. Ntoumenopoulos

Leptospirosis in Reunion Island (Indian Ocean): analysis of factors associated with severity in 147 confirmed cases