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Published in:

01-05-2004 | Review

Stress-hyperglycemia, insulin and immunomodulation in sepsis

Authors: Paul E. Marik, Murugan Raghavan

Published in: Intensive Care Medicine | Issue 5/2004

Abstract

Stress-hyperglycemia and insulin resistance are exceedingly common in critically ill patients, particularly those with sepsis. Multiple pathogenetic mechanisms are responsible for this metabolic syndrome; however, increased release of pro-inflammatory mediators and counter-regulatory hormones may play a pivotal role. Recent data suggests that hyperglycemia may potentiate the pro-inflammatory response while insulin has the opposite effect. Furthermore, emerging evidence suggests that tight glycemic control will improve the outcome of critically ill patients. This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder.

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Title: Stress-hyperglycemia, insulin and immunomodulation in sepsis
Authors: Paul E. Marik
Murugan Raghavan
Publication date: 01-05-2004
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2167-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Stress-hyperglycemia, insulin and immunomodulation in sepsis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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