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Diabetologia
Published in: Diabetologia 11/2008

01-11-2008 | Research Letter

Genetic variation in the NOS1AP gene is associated with the incidence of diabetes mellitus in users of calcium channel blockers

Authors: M. L. Becker, L. E. Visser, C. Newton-Cheh, J. C. M. Witteman, A. Hofman, A. G. Uitterlinden, B. H. Ch. Stricker

Published in: Diabetologia | Issue 11/2008

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Excerpt

To the Editor: Nitric oxide (NO) is an important regulator of a number of intracellular processes, including the secretion of insulin by the pancreatic beta cell. NO, produced by neuronal nitric oxide synthases (nNOS), is essential for normal beta cell functioning, and it has also been suggested that nNOS might have a role in the pathogenesis of diabetes mellitus [1‐3]. …
Literature
1.
Lajoix AD, Reggio H, Chardes T et al (2001) A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Diabetes 50:1311–1323PubMedCrossRef
2.
Lajoix AD, Pugniere M, Roquet F et al (2004) Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response. Diabetes 53:1467–1474PubMedCrossRef
3.
Shankar RR, Wu Y, Shen HQ, Zhu JS, Baron AD (2000) Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. Diabetes 49:684–687PubMedCrossRef
4.
Arking DE, Pfeufer A, Post W et al (2006) A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 38:644–651PubMedCrossRef
5.
Aarnoudse AJ, Newton-Cheh C, de Bakker PI et al (2007) Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. Circulation 116:10–16PubMedCrossRef
6.
Schulz R, Rassaf T, Massion PB, Kelm M, Balligand JL (2005) Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol Ther 108:225–256PubMedCrossRef
7.
Ashcroft FM, Rorsman P (1989) Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 54:87–143PubMedCrossRef
8.
Hofman A, Breteler MM, van Duijn CM et al (2007) The Rotterdam Study: objectives and design update. Eur J Epidemiol 22:819–829PubMedCrossRef
Metadata
Title
Genetic variation in the NOS1AP gene is associated with the incidence of diabetes mellitus in users of calcium channel blockers
Authors
M. L. Becker
L. E. Visser
C. Newton-Cheh
J. C. M. Witteman
A. Hofman
A. G. Uitterlinden
B. H. Ch. Stricker
Publication date
01-11-2008
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 11/2008
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-008-1143-4

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Keynote webinar | Spotlight on medication adherence

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