Published in:
01-03-2007 | For Debate
C-peptide: a redundant relative of insulin?
Authors:
L. Luzi, G. Zerbini, A. Caumo
Published in:
Diabetologia
|
Issue 3/2007
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Excerpt
Historically, focus on C-peptide has been relegated to the exploitation of its peculiar pharmacokinetics (i.e. distribution and elimination) to derive accurate assessment of beta cell secretion, whereas, more recently, greater interest has been placed on its pharmacodynamics (i.e. the biological actions it exerts). In the present paper we will address the latter subject, but to put things in perspective—and because it is well known that kinetics and the time course of dynamics are intimately linked—we will begin with a brief overview of the kinetic properties of C-peptide. …