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Inflammation Research
Published in: Inflammation Research 9/2016

01-09-2016 | Original Research Paper

Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women

Authors: Lu Zhou, Li Cheng, Yun He, Yin Gu, Yejun Wang, Chenhong Wang

Published in: Inflammation Research | Issue 9/2016

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Abstract

Objectives

To investigate the association of polymorphisms in genes involved in coagulation, fibrinolysis, and inflammation with pre-eclampsia (PE) in a Chinese population.

Methods

It is a case–control study of patients with PE (n = 117) and controls (n = 286) from the Maternal and Children’s Hospital of Shenzhen City carried out between June 2014 and May 2015. The rs6025, rs6020, rs1801133, rs1799963, rs1799889, rs231775, rs1800896, rs1800629, and rs1799724 polymorphisms were analyzed using Snap Shot. Multifactor dimensionality reduction (MDR) and logistic regression analyses were carried out to assess the interactions among these SNPs.

Results

The frequencies of polymorphisms in tumor necrosis factor-α (TNF-α) (rs1800629 and rs1799724) and interleukin 10 (IL-10) (rs1800896) were significantly different between patients with PE and controls (P < 0.05). The best interaction model identified a marginally significant interaction between rs1799724 and rs1800896 (P = 0.05).

Conclusions

This study suggests that polymorphisms in the TNF-α and IL-10 genes could be associated with PE, but additional studies are necessary to explore the mechanisms involving these polymorphisms and the gene–gene interactions involved in the susceptibility to PE.
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Metadata
Title
Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women
Authors
Lu Zhou
Li Cheng
Yun He
Yin Gu
Yejun Wang
Chenhong Wang
Publication date
01-09-2016
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 9/2016
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-016-0953-y

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