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Reproductive Health
Published in: Reproductive Health 1/2024

Open Access 01-12-2024 | Endometriosis | Review

Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis

Authors: Pooya Farhangnia, Morvarid Noormohammadi, Ali-Akbar Delbandi

Published in: Reproductive Health | Issue 1/2024

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Abstract

Vitamin D is a fat-soluble steroid hormone that was initially known only for regulating calcium and phosphorus levels and maintaining bone health. However, it was later discovered that many organs express vitamin D metabolizing enzymes and have a ligand for vitamin D, which regulates the expression of an extensive assortment of genes. As a result, vitamin D is indispensable for the proper function of organs, and its deficiency is believed to be a critical factor in symptoms and disorders such as cardiovascular diseases, autoimmune diseases, and cancers. The significance of vitamin D in reproductive tissues was recognized later, and studies have revealed its crucial role in male and female fertility, as well as proper reproductive function during pregnancy. Vitamin D deficiency has been identified as a risk factor for infertility, gonadal cancers, pregnancy complications, polycystic ovary syndrome, and endometriosis. However, data investigating the association between vitamin D levels and reproductive disorders, including endometriosis, have encountered inconsistencies. Therefore, the present study aims to review existing research on the effect of vitamin D on proper reproductive function, and the role of deficiency in reproductive diseases and specifically focuses on endometriosis.
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Metadata
Title
Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis
Authors
Pooya Farhangnia
Morvarid Noormohammadi
Ali-Akbar Delbandi
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Reproductive Health / Issue 1/2024
Electronic ISSN: 1742-4755
DOI
https://doi.org/10.1186/s12978-024-01797-y

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